Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR -mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance.
Heon S, Nishino M, Goldberg S, Porter J, Sequist L, Jackman D, Johnson B. Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR -mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance. Journal Of Clinical Oncology 2012, 30: 7525-7525. DOI: 10.1200/jco.2012.30.15_suppl.7525.Peer-Reviewed Original ResearchNon-small cell lung cancerDrug-free intervalAdvanced non-small cell lung cancerEGFR-TKIEGFR mutationsMedian PFSMutant non-small cell lung cancerEGFR-mutant non-small cell lung cancerEGFR-mutant advanced non-small cell lung cancerSingle-agent gefitinibObjective tumor responseCell lung cancerSensitizing EGFR mutationsEGFR T790MNSCLC ptsRECIST 1.1Systemic regimensProspective trialMedian intervalRetrospective studyLung cancerTumor responseFree intervalPIK3CA mutationsRadiographic assessment