2022
A phase 1/2 study of the highly selective EGFR inhibitor, BLU-701, in patients with EGFR-mutant non–small cell lung cancer (NSCLC).
Spira A, Spigel D, Camidge D, De Langen A, Kim T, Goto K, Elamin Y, Shum E, Reckamp K, Rotow J, Goldberg S, Gadgeel S, Leal T, Albayya F, Fitzpatrick S, Louie-Gao M, Parepally J, Zalutskaya A, Yu H. A phase 1/2 study of the highly selective EGFR inhibitor, BLU-701, in patients with EGFR-mutant non–small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2022, 40: tps9142-tps9142. DOI: 10.1200/jco.2022.40.16_suppl.tps9142.Peer-Reviewed Original ResearchNon-small cell lung cancerEGFRm non-small cell lung cancerTyrosine kinase inhibitorsOverall response ratePrimary endpointEastern Cooperative Oncology Group performance status 0EGFR-mutant non-small cell lung cancerPhase 1 dose escalationPhase 2 primary endpointOral tyrosine kinase inhibitorGeneration tyrosine kinase inhibitorsResistance mutationsEGFR T790M mutationDisease control rateKey exclusion criteriaPerformance status 0Phase 1/2 studyPhase 2 doseProgression-free survivalPlatinum-based chemotherapyCell lung cancerDuration of responseCentral nervous system activityKey inclusion criteriaPK/pharmacodynamics
2017
Circulating tumor DNA (ctDNA) to monitor treatment response and progression in patients treated with tyrosine kinase inhibitors (TKIs) and immunotherapy for EGFR-mutant non-small cell lung cancer (NSCLC).
Henick B, Goldberg S, Narayan A, Rossi C, Rodney S, Kole A, Politi K, Gettinger S, Herbst R, Patel A. Circulating tumor DNA (ctDNA) to monitor treatment response and progression in patients treated with tyrosine kinase inhibitors (TKIs) and immunotherapy for EGFR-mutant non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2017, 35: e20652-e20652. DOI: 10.1200/jco.2017.35.15_suppl.e20652.Peer-Reviewed Original ResearchNon-small cell lung cancerTyrosine kinase inhibitorsEGFR-mutant non-small cell lung cancerCtDNA levelsDisease progressionRadiographic progressionTKI therapyEGFR mutationsEGFR mutation-positive non-small cell lung cancerMutation-positive non-small cell lung cancerT790MAnti-PD-1 monotherapyEGFR mutation-positive patientsPD-1 inhibitor monotherapyEGFR-mutant NSCLC patientsSubset of patientsCell lung cancerMutation-positive patientsAssessment of responseLow ctDNA levelsChart reviewClinical characteristicsDurable responsesInhibitor monotherapyNSCLC patients
2012
Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR -mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance.
Heon S, Nishino M, Goldberg S, Porter J, Sequist L, Jackman D, Johnson B. Response to EGFR tyrosine kinase inhibitor (TKI) retreatment after a drug-free interval in EGFR -mutant advanced non-small cell lung cancer (NSCLC) with acquired resistance. Journal Of Clinical Oncology 2012, 30: 7525-7525. DOI: 10.1200/jco.2012.30.15_suppl.7525.Peer-Reviewed Original ResearchNon-small cell lung cancerDrug-free intervalAdvanced non-small cell lung cancerEGFR-TKIEGFR mutationsMedian PFSMutant non-small cell lung cancerEGFR-mutant non-small cell lung cancerEGFR-mutant advanced non-small cell lung cancerSingle-agent gefitinibObjective tumor responseCell lung cancerSensitizing EGFR mutationsEGFR T790MNSCLC ptsRECIST 1.1Systemic regimensProspective trialMedian intervalRetrospective studyLung cancerTumor responseFree intervalPIK3CA mutationsRadiographic assessment