Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells
Park S, Kim S, Kim K, Yu S, Choi H, Kim Y, Nam H, Seo Y, Ahn S. Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells. Pharmacological Reports 2016, 69: 90-96. PMID: 27912102, DOI: 10.1016/j.pharep.2016.10.014.Peer-Reviewed Original ResearchConceptsProstate cancer PC-3 cellsPC-3 cellsCancer PC-3 cellsOxygen species productionROS productionERK MAPKNon-malignant RWPE-1 cellsExtracellular signal-regulated kinase (ERK) activityMitochondrial dysfunctionSpecies productionMitochondrial membrane potentialCell cycle arrestHuman prostate cancer PC-3 cellsReactive oxygen species productionCell viabilityRWPE-1 cellsProtein kinaseStreptomyces speciesKinase activityReactive oxygen speciesERK activationMolecular mechanismsP38 activationMAPK proteinsApoptotic effects