2016
Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells
Park S, Kim S, Kim K, Yu S, Choi H, Kim Y, Nam H, Seo Y, Ahn S. Toyocamycin induces apoptosis via the crosstalk between reactive oxygen species and p38/ERK MAPKs signaling pathway in human prostate cancer PC-3 cells. Pharmacological Reports 2016, 69: 90-96. PMID: 27912102, DOI: 10.1016/j.pharep.2016.10.014.Peer-Reviewed Original ResearchConceptsProstate cancer PC-3 cellsPC-3 cellsCancer PC-3 cellsOxygen species productionROS productionERK MAPKNon-malignant RWPE-1 cellsExtracellular signal-regulated kinase (ERK) activityMitochondrial dysfunctionSpecies productionMitochondrial membrane potentialCell cycle arrestHuman prostate cancer PC-3 cellsReactive oxygen species productionCell viabilityRWPE-1 cellsProtein kinaseStreptomyces speciesKinase activityReactive oxygen speciesERK activationMolecular mechanismsP38 activationMAPK proteinsApoptotic effects
2013
Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells
Kim S, Kim K, Yu S, Park S, Kong I, Ahn S. Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb103-lb103. DOI: 10.1096/fasebj.27.1_supplement.lb103.Peer-Reviewed Original ResearchPC-3 cellsHuman prostate cancer PC-3 cellsProstate cancer PC-3 cellsSilibinin-induced apoptosisCancer PC-3 cellsER stress-related proteinsStress-related proteinsReactive oxygen speciesER stressDNA damage-inducible gene 153Cancer cellsRWPE-1 cellsChelator BAPTA/AMProstate cancer cellsDrug-induced lethalityGlucose-regulated protein 78Mitochondrial-mediated apoptosisFlow cytometric analysisMitochondrial membrane potentialApoptosis-related proteinsBAPTA/AMCancer cell linesSilibinin treatmentChemopreventive effectsDisruption of Ca2