Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells
Kim K, Kim S, Yu S, Park S, Kim Y, Nam H, An H, Yu H, Kim Y, Ji J, Seo Y, Ahn S. Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells. Biomedicine & Pharmacotherapy 2017, 88: 1016-1024. PMID: 28178613, DOI: 10.1016/j.biopha.2017.01.140.Peer-Reviewed Original ResearchConceptsProstate cancer cellsHuman prostate cancer cellsAcidic vesicular organelles (AVOs) formationApoptotic cell death pathwayCancer cellsCell death pathwaysProtein 1 light chain 3Cell cycle arrestLight chain 3Human prostate cancer PC-3 cellsProstate cancer PC-3 cellsReactive oxygen species productionPossible signal pathwaysCancer PC-3 cellsInhibition of autophagyOrganelle formationDeath pathwaysNew potential chemotherapeutic agentsReactive oxygen speciesOxygen species productionMitochondrial hyperpolarizationMolecular mechanismsPotential chemotherapeutic agentProduction of ROSCytoprotective autophagy