Lasalocid induces apoptosis via the cell cycle arrest and ROS‐mediated mitochondrial pathway in prostate cancer PC‐3 cells
Kim K, Kim S, Yu S, Park S, Kong2 I, Ahn S. Lasalocid induces apoptosis via the cell cycle arrest and ROS‐mediated mitochondrial pathway in prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb206-lb206. DOI: 10.1096/fasebj.27.1_supplement.lb206.Peer-Reviewed Original ResearchProstate cancer cellsHuman prostate cancer cellsCancer cellsPC-3 cellsCaspase-3 substrateMitochondrial membrane hyperpolarizationCaspase-dependent apoptosisMitochondrial membrane potentialCell cycle arrestProstate cancer PC-3 cellsCancer PC-3 cellsMitochondrial pathwayIntracellular ROS levelsTriggers apoptosisLevels of BaxPARP-1Cycle arrestSignal pathwayAssociated signal pathwayROS levelsCaspase-3Bcl-2ApoptosisElevated oxidative stressMembrane potential