Salinomycin Induces Reactive Oxygen Species and Apoptosis in Aggressive Breast Cancer Cells as Mediated with Regulation of Autophagy
Kim K, Park K, Kim S, Yu S, Lee D, Kim Y, Noh K, Ma J, Seo Y, Ahn S. Salinomycin Induces Reactive Oxygen Species and Apoptosis in Aggressive Breast Cancer Cells as Mediated with Regulation of Autophagy. Anticancer Research 2017, 37: 1747-1758. PMID: 28373437, DOI: 10.21873/anticanres.11507.Peer-Reviewed Original ResearchConceptsMDA-MB-231 cellsAggressive breast cancer cellsBreast cancer cellsCancer cellsReactive oxygen speciesBreast cancer cell linesROS productionMitochondrial membrane potentialScavenger of ROSInduces reactive oxygen speciesCancer cell linesCaspase-3/9 activityPropidium iodide stainingMCF-7 cellsOxygen speciesAcceleration of apoptosisAcridine orange stainingAutophagy inhibitionMonocarboxylic ionophoreChemotherapeutic drugsCancer treatmentMitochondrial dysfunctionIodide stainingRegulation of autophagyUnderlying mechanism