2016
Monensin Induces PC-3 Prostate Cancer Cell Apoptosis via ROS Production and Ca2+ Homeostasis Disruption
KIM S, KIM K, YU S, PARK S, YU H, SEO Y, AHN S. Monensin Induces PC-3 Prostate Cancer Cell Apoptosis via ROS Production and Ca2+ Homeostasis Disruption. Anticancer Research 2016, 36: 5835-5843. PMID: 27793906, DOI: 10.21873/anticanres.11168.Peer-Reviewed Original ResearchConceptsCell cycle arrestApoptosis-related proteinsCell cycleCancer cellsPoly ADP-ribose polymerase (PARP) cleavageADP-ribose polymerase cleavageDisruption of CaProstate cancer cell apoptosisRibose polymerase cleavagePhase cell cycle arrestHuman prostate cancer cellsCell viabilityReactive oxygen species productionCancer cell apoptosisAnticancer effectsOxygen species productionMitochondrial ROS inhibitorProduction of ROSMitochondrial ROSDependent apoptosisProstate cancer cellsProstate cell linesPolymerase cleavageCell growth inhibitionPC-3 cells
2015
Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells
Kim S, Kim K, Yu S, Park S, Choi H, Ji J, Ahn S. Autophagy inhibition enhances silibinin-induced apoptosis by regulating reactive oxygen species production in human prostate cancer PC-3 cells. Biochemical And Biophysical Research Communications 2015, 468: 151-156. PMID: 26522224, DOI: 10.1016/j.bbrc.2015.10.143.Peer-Reviewed Original ResearchConceptsPC-3 cellsProstate cancer PC-3 cellsCancer PC-3 cellsAcidic vesicular organellesSilibinin-induced apoptosisReactive oxygen speciesAnticancer effectsHuman prostate cancer PC-3 cellsMicrotubule-associated protein 1 light chain 3Inhibition of ROSProtein 1 light chain 3Major bioactive componentsInhibition of autophagyReactive oxygen species productionCancer cell linesLight chain 3Supportive therapyLiver conditionsOxygen species productionCancer modelProtective roleSilibininSilibinin-induced autophagyROS inhibitorChain 3
2011
Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells
Kim S, Kim K, Yu S, Jeon H, Jin Y, Lee C, Ahn S. Silibinin Inhibits Cell Growth and Induces Apoptosis through Cell-cycle Arrest in PC-3 Prostate Cancer Cells. Journal Of Life Science 2011, 21: 1573-1578. DOI: 10.5352/jls.2011.21.11.1573.Peer-Reviewed Original ResearchCell cycle check point proteinsCell cycle arrestDose-dependent mannerCheck point proteinsPC-3Cycle arrestProstate cancer cell line PC-3Cancer cell line PC-3Cyclin-dependent kinases 2/4/6PC-3 prostate cancer cellsCell line PC-3Milk thistleProstate cancer cells PC-3Prostate cancer cellsPC-3 cellsPI double stainingCancer cell linesCell growthInhibits cell growthChemopreventive effectsPoly (ADP-ribose) polymerase cleavageAnticancer effectsFlow cytometryRadical scavenger activityCaspase-3 activation