Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells
Lee W, Kim K, Yu S, Kim S, Chun S, Ji J, Yu H, Ahn S. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochemical And Biophysical Research Communications 2012, 430: 406-412. PMID: 23159637, DOI: 10.1016/j.bbrc.2012.11.030.Peer-Reviewed Original ResearchConceptsPC-3 cellsHuman prostate cancer PC-3 cellsProstate cancer PC-3 cellsCancer PC-3 cellsReactive oxygen speciesAndrogen-independent PC-3LNCaP prostate cellsCaspase-3 assay kitHuman prostate cancerProstate cancer cellsIncrease of intracellularInduces reactive oxygen speciesTime-dependent mannerProstate cancerPiper longum LinnCleavage of PARPProstate cellsN-acetylcysteineAntiproliferation effectCyclin D1Caspase-3 activationAssay KitBcl-2 proteinCandidate agentCancer cells