Platelet endothelial cell adhesion molecule‐1 modulates endothelial cell motility through the small G‐protein Rho
Gratzinger D, Canosa S, Engelhardt B, Maori J. Platelet endothelial cell adhesion molecule‐1 modulates endothelial cell motility through the small G‐protein Rho. The FASEB Journal 2003, 17: 1458-1469. PMID: 12890700, DOI: 10.1096/fj.02-1040com.Peer-Reviewed Original ResearchConceptsWound healing migrationSingle cell motilityCell motilityHealing migrationRho activityPECAM-1-positive endothelial cellsSmall G protein RhoGTPase-activating proteinsG-protein componentsImmunoreceptor tyrosine-based inhibitory motifG protein RhoEndothelial cell adhesion molecule-1Seven-transmembrane receptorsEndothelial cell motilityTyrosine-based inhibitory motifEndothelial cellsPECAM-1Endothelial cell migrationWound healing defectsExtracellular domainCell adhesion molecule-1Coordinated activationInhibitory motifCell migrationExtension formationPECAM-1 promotes β-catenin accumulation and stimulates endothelial cell proliferation
Biswas P, Canosa S, Schoenfeld J, Schoenfeld D, Tucker A, Madri JA. PECAM-1 promotes β-catenin accumulation and stimulates endothelial cell proliferation. Biochemical And Biophysical Research Communications 2003, 303: 212-218. PMID: 12646189, DOI: 10.1016/s0006-291x(03)00313-9.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBeta CateninBlotting, WesternCell AdhesionCell DivisionCytoplasmCytoskeletal ProteinsEndotheliumFlow CytometryHumansLungMiceMice, KnockoutMicroscopy, FluorescencePlatelet Endothelial Cell Adhesion Molecule-1Precipitin TestsSignal TransductionTrans-ActivatorsTranscription, GeneticTransfectionConceptsPECAM-1-positive endothelial cellsBeta-catenin proteinCell proliferationEndothelial cellsPECAM-1Beta-catenin localizationCytoplasmic domainΒ-catenin accumulationFull-length PECAM-1Functional consequencesEndothelial cell proliferationCell membraneKnockout animalsAdhesion moleculesLess accumulationCellsAccumulationProliferative rateProliferationMembraneProteinBinds