2017
A Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy
Mishra SK, Kannan S. A Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy. Inorganic Chemistry 2017, 56: 12054-12066. PMID: 28933536, DOI: 10.1021/acs.inorgchem.7b02103.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAntineoplastic AgentsChitosanContrast MediaDrug CarriersDrug LiberationGreen Chemistry TechnologyHeatingHeLa CellsHumansMagnetic Resonance ImagingMetal NanoparticlesMultimodal ImagingNeodymiumOptical ImagingPaclitaxelParticle SizeSilverTheranostic NanomedicineTomography, X-Ray ComputedConceptsChemo-photothermal therapyPhotothermal effectMicrowave-assisted polyol synthesisCombined chemo-photothermal therapyMRI/CT imagingEfficient photothermal effectHigh loading efficiencyLoading of paclitaxelTheranostic nanoparticlesBimetallic nanoparticlesMetallic nanostructuresGood monodispersityPolyol synthesisNIR laserLoading efficiencyAverage sizeNanoparticlesGood biocompatibilityMultimodal imagingInfrared regionExcellent candidateNIR imagingChitosan functionalizationSynergistic effectDrug molecules
2016
Copper incorporated microporous chitosan-polyethylene glycol hydrogels loaded with naproxen for effective drug release and anti-infection wound dressing
Mishra S, Mary D, Kannan S. Copper incorporated microporous chitosan-polyethylene glycol hydrogels loaded with naproxen for effective drug release and anti-infection wound dressing. International Journal Of Biological Macromolecules 2016, 95: 928-937. PMID: 27984151, DOI: 10.1016/j.ijbiomac.2016.10.080.Peer-Reviewed Original ResearchConceptsMoisture permeabilityEnhanced mechanical stabilityStability of filmsDrug releaseCell adhesion testsIncorporated hydrogelsMechanical propertiesEfficiency of CuMicroporous surfaceAbsorption capabilityAdhesion testHydrogel filmsMechanical stabilityChitosan filmsFilmsAntibacterial testsDegradation studiesHydrated conditionsRelease of CuWound dressingsGlycol hydrogelsEffective drug releaseHydrogelsCopper ionsCuIn Situ Impregnation of Silver Nanoclusters in Microporous Chitosan-PEG Membranes as an Antibacterial and Drug Delivery Percutaneous Device
Mishra SK, Raveendran S, Ferreira JM, Kannan S. In Situ Impregnation of Silver Nanoclusters in Microporous Chitosan-PEG Membranes as an Antibacterial and Drug Delivery Percutaneous Device. Langmuir 2016, 32: 10305-10316. PMID: 27685160, DOI: 10.1021/acs.langmuir.6b02844.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsAnti-Bacterial AgentsBiofilmsCattleCell Line, TumorChickensChitosanDrug CarriersDrug LiberationElastic ModulusEscherichia coliHumansHydrogen PeroxideMembranes, ArtificialMetal NanoparticlesMuramidaseNaproxenParticle SizePolyethylene GlycolsSilverStaphylococcus aureusSurface PropertiesConceptsMultifunctional devicesSilver nanoclustersSitu synthesis methodEfficient antibacterial activityDrug deliverySitu impregnationSynthesis methodCharacterization techniquesDrug releaseSustainable releaseLocal drug deliveryFormation of fluorescentMechanical stabilityBiofilm inhibitionAgNCsMicroporous membranesDevicesPresence of lysozymeAntibacterial activityNanoclustersMultiple arraysPercutaneous devicesBiocompatibilityAnti-inflammatory drug naproxenBiofilm formation
2014
Mechanically stable antimicrobial chitosan–PVA–silver nanocomposite coatings deposited on titanium implants
Mishra SK, Ferreira JM, Kannan S. Mechanically stable antimicrobial chitosan–PVA–silver nanocomposite coatings deposited on titanium implants. Carbohydrate Polymers 2014, 121: 37-48. PMID: 25659669, DOI: 10.1016/j.carbpol.2014.12.027.Peer-Reviewed Original ResearchConceptsSilver nanoparticlesAqueous solutionBionanocomposite coatingsSlow sustained releaseSilver nanocomposite coatingsAntimicrobial activityIncorporation of PVAContent of PVAColloidal solsSynthesis routeSolvent evaporationSilver ionsChitosan matrixSilver nitrateNanocomposite coatingsSustained releasePolyvinyl alcoholPVATitanium substrateBionanocompositesAntimicrobial activity testChitosan-PVACoated specimensCoatingsMechanical stabilityDevelopment, mechanical evaluation and surface characteristics of chitosan/polyvinyl alcohol based polymer composite coatings on titanium metal
Mishra SK, Kannan S. Development, mechanical evaluation and surface characteristics of chitosan/polyvinyl alcohol based polymer composite coatings on titanium metal. Journal Of The Mechanical Behavior Of Biomedical Materials 2014, 40: 314-324. PMID: 25265031, DOI: 10.1016/j.jmbbm.2014.08.014.Peer-Reviewed Original ResearchConceptsMechanical propertiesTi metalTitanium metalPolymer composite coatingsHigh mechanical propertiesVariable elastic modulusComposite polymer filmsTi metal surfaceChitosan/polyvinyl alcoholCoated specimensComposite coatingsPolymer compositesGood adhesionHydrated coatingsElastic modulusMechanical evaluationOrthopedic implantsMechanical stabilityScratch testCoatingsPolymer filmsStable coatingSurface characteristicsPolyvinyl alcoholVolume solution