Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress
Boehm A, Steiner S, Zaehringer F, Casanova A, Hamburger F, Ritz D, Keck W, Ackermann M, Schirmer T, Jenal U. Second messenger signalling governs Escherichia coli biofilm induction upon ribosomal stress. Molecular Microbiology 2009, 72: 1500-1516. PMID: 19460094, DOI: 10.1111/j.1365-2958.2009.06739.x.Peer-Reviewed Original ResearchMeSH KeywordsAdhesins, BacterialAnti-Bacterial AgentsBeta-GlucansBiofilmsCyclic GMPEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialGuanosine TetraphosphatePhosphorus-Oxygen LyasesProtein BiosynthesisPyrophosphatasesRibosomesRNA Processing, Post-TranscriptionalSecond Messenger SystemsConceptsBiofilm inductionRibosome-targeting antibioticsNovel regulatory mechanismSecond messenger signalingSpecific derepressionBiosynthesis machineryRibosomal stressTranslational stressTranslation inhibitorsPpGpp levelsExposure of bacteriaMicrobial cellsRegulatory mechanismsAdhesin productionPolysaccharide adhesinBiofilm formationPpGppImportant synergistic roleMaximal inductionBiofilm controlMachineryBiofilm modelInductionGMPSubinhibitory concentrations