Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction
Steiner S, Lori C, Boehm A, Jenal U. Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction. The EMBO Journal 2012, 32: 354-368. PMID: 23202856, PMCID: PMC3567491, DOI: 10.1038/emboj.2012.315.Peer-Reviewed Original ResearchConceptsProtein-protein interactionsSecond messenger cInner membrane componentsEscherichia coli biofilmsGMP receptorGMP signalingGMP bindsSynthesis machineryExtracellular matrix componentsMajor extracellular matrix componentsAllosteric activationExopolysaccharide synthesisExopolysaccharide matrixMembrane componentsColi biofilmsGlycosyltransferase activityBacterial pathogensMachineryN-acetylglucosaminePathogenic bacteriaMatrix componentsEnzyme activityGMP concentrationGMPBacteria