2013
Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells
Katz SG, LaBelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood 2013, 123: 884-893. PMID: 24352880, PMCID: PMC3916879, DOI: 10.1182/blood-2013-04-499079.Peer-Reviewed Original ResearchConceptsMantle cell lymphomaCyclin D1 transgenic miceCyclin D1 overexpressionB cellsCell lymphomaAggressive B-cell lymphomasSubset of miceTransgenic mouse modelB-cell lymphomaDeletion of BimPathogenesis of MCLHuman mantle cell lymphomaDevelopment of MCLStimulation regimensConventional chemotherapyMouse modelLymphoid maturationTransgenic miceLymphomaBIM deletionSelective expansionMiceProapoptotic BimPathogenesisGenetic aberrations
2008
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors
Beuling E, Bosse T, de Kerk D, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Developmental Biology 2008, 322: 179-189. PMID: 18692040, PMCID: PMC3031907, DOI: 10.1016/j.ydbio.2008.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCell DifferentiationCell ProliferationEnterocytesGATA4 Transcription FactorGene Expression RegulationIntestinal AbsorptionIntestinal MucosaIntestine, SmallMiceMice, TransgenicNuclear ProteinsOrgan SpecificityOrganic Anion Transporters, Sodium-DependentRNA, MessengerSymportersTranscription FactorsTranscriptional ActivationConceptsFriend of GATAGene repressionCell fate determinationFamily of cofactorsMammalian small intestineProximal-distal patternRepression functionGata (FOG) cofactorsFate determinationCell lineage markersFOG cofactorsGATA factorsGATA4 mutantsGene activationTranscription factorsGATA4 functionIntestinal epithelial cellsGATA4Multiple tissuesRepressionLineage markersMouse small intestineCofactorEpithelial cellsGenes
2003
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development
Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14030-14035. PMID: 14614148, PMCID: PMC283540, DOI: 10.1073/pnas.1936250100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsDNA-Binding ProteinsEndotheliumErythroid-Specific DNA-Binding FactorsFetal HeartGATA1 Transcription FactorHeart Defects, CongenitalHeart ValvesHematopoiesisIn Situ HybridizationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeural CrestNuclear ProteinsTranscription FactorsConceptsFOG-1GATA-4/5/6FOG-2Cardiac developmentConditional inactivationGATA transcription factorsDiverse cell typesNeural crest cellsNeural crest derivativesGata (FOG) cofactorsEmbryonic day 14.5Cofactor FriendTranscription factorsHematopoietic defectsHeart developmentCrest cellsTransgenic rescueCrest derivativesUnsuspected roleGATA-4Nonredundant requirementCell typesCell of originDay 14.5Atrioventricular valve
2001
Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells
Zhou M, Ouyang W, Gong Q, Katz S, White J, Orkin S, Murphy K. Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells. Journal Of Experimental Medicine 2001, 194: 1461-1471. PMID: 11714753, PMCID: PMC2193678, DOI: 10.1084/jem.194.10.1461.Peer-Reviewed Original ResearchConceptsFOG-1Friend of GATATranscription factor activityActivator of transcriptionIL-5 promoterHematopoietic developmentMegakaryocyte differentiationSignal transducerGATA-3Dependent inductionFactor activityNaive T cellsTh2 developmentT cellsOverexpressionAutoactivationCellsGATA-3 expressionPrimary activationActivationInductionTranscriptionPromoterGATAProtein