2019
A versatile flow-based assay for immunocyte-mediated cytotoxicity
Rabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG. A versatile flow-based assay for immunocyte-mediated cytotoxicity. Journal Of Immunological Methods 2019, 474: 112668. PMID: 31525367, PMCID: PMC6891822, DOI: 10.1016/j.jim.2019.112668.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell NucleusCytotoxicity Tests, ImmunologicCytotoxicity, ImmunologicFlow CytometryHigh-Throughput Screening AssaysHumansImmunotherapy, AdoptiveKiller Cells, NaturalLymphocytes, Tumor-InfiltratingMaleMelanomaMice, Inbred C57BLPredictive Value of TestsReceptors, Chimeric AntigenReproducibility of ResultsSkin NeoplasmsTime FactorsT-LymphocytesWorkflowConceptsCell-mediated cytotoxicityTumor-Infiltrating LymphocytesEffector cellsTarget cellsNK-92 cellsChimeric antigen receptorNuclear staining patternInfiltrating lymphocytesT cellsEffector nucleiFlow-based assayImmune systemFlow cytometryStaining patternAntigen receptorDead cellsKilling reactionCytotoxicityCell permeable dyeCellsAssaysCell mixturesNuclear proteinsNovel strategyCell proteins
2013
Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells
Katz SG, LaBelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood 2013, 123: 884-893. PMID: 24352880, PMCID: PMC3916879, DOI: 10.1182/blood-2013-04-499079.Peer-Reviewed Original ResearchConceptsMantle cell lymphomaCyclin D1 transgenic miceCyclin D1 overexpressionB cellsCell lymphomaAggressive B-cell lymphomasSubset of miceTransgenic mouse modelB-cell lymphomaDeletion of BimPathogenesis of MCLHuman mantle cell lymphomaDevelopment of MCLStimulation regimensConventional chemotherapyMouse modelLymphoid maturationTransgenic miceLymphomaBIM deletionSelective expansionMiceProapoptotic BimPathogenesisGenetic aberrations
2003
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development
Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14030-14035. PMID: 14614148, PMCID: PMC283540, DOI: 10.1073/pnas.1936250100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsDNA-Binding ProteinsEndotheliumErythroid-Specific DNA-Binding FactorsFetal HeartGATA1 Transcription FactorHeart Defects, CongenitalHeart ValvesHematopoiesisIn Situ HybridizationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeural CrestNuclear ProteinsTranscription FactorsConceptsFOG-1GATA-4/5/6FOG-2Cardiac developmentConditional inactivationGATA transcription factorsDiverse cell typesNeural crest cellsNeural crest derivativesGata (FOG) cofactorsEmbryonic day 14.5Cofactor FriendTranscription factorsHematopoietic defectsHeart developmentCrest cellsTransgenic rescueCrest derivativesUnsuspected roleGATA-4Nonredundant requirementCell typesCell of originDay 14.5Atrioventricular valve