Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK
Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 2012, 32: 4078-4085. PMID: 22986529, PMCID: PMC3529761, DOI: 10.1038/onc.2012.421.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProapoptotic Bcl-2 family proteins BaxSubventricular zoneBcl-2 family proteins BaxProgenitor cellsLong-term pathophysiological consequencesMitochondrial outer membraneBax/BakDeletion of BaxStem cell nicheHigh-grade tumorsMultiple developmental abnormalitiesIntrinsic apoptotic pathwayOlfactory bulb regionNestin-positive cellsProgenitor cell poolCellular excessDeath stimuliLoss of functionHypercellular tumorOuter membraneTesticular tumorsCell nicheLong-term regulationApoptotic pathway