2012
Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK
Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene 2012, 32: 4078-4085. PMID: 22986529, PMCID: PMC3529761, DOI: 10.1038/onc.2012.421.Peer-Reviewed Original ResearchConceptsNeural progenitor cellsProapoptotic Bcl-2 family proteins BaxSubventricular zoneBcl-2 family proteins BaxProgenitor cellsLong-term pathophysiological consequencesMitochondrial outer membraneBax/BakDeletion of BaxStem cell nicheHigh-grade tumorsMultiple developmental abnormalitiesIntrinsic apoptotic pathwayOlfactory bulb regionNestin-positive cellsProgenitor cell poolCellular excessDeath stimuliLoss of functionHypercellular tumorOuter membraneTesticular tumorsCell nicheLong-term regulationApoptotic pathway
2008
BAX activation is initiated at a novel interaction site
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng E, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature 2008, 455: 1076-1081. PMID: 18948948, PMCID: PMC2597110, DOI: 10.1038/nature07396.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisApoptosis Regulatory ProteinsBcl-2-Associated X ProteinBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinCell LineGene Expression RegulationHumansMembrane ProteinsMiceMutagenesis, Site-DirectedMutationNuclear Magnetic Resonance, BiomolecularProtein BindingProto-Oncogene ProteinsSequence AlignmentConceptsAnti-apoptotic proteinsInteraction sitesBax activationBax-mediated cell deathBCL-2 domainsCell deathBcl-2 familyNovel interaction sitePro-apoptotic proteinsPoint mutagenesisMitochondrial apoptosisBax interactionStress stimuliΑ-helixProteinNew targetsBaxTherapeutic modulationDirect activationActivation siteApoptosisActivationFunctional activitySitesMutagenesis