SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis
Kuo P, Jiang Z, Perumal D, Leshchenko V, Lagana' A, Katz S, Walensky L, Shaknovich R, Ye B, Parekh S. SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis. Blood 2015, 126: 1253. DOI: 10.1182/blood.v126.23.1253.1253.Peer-Reviewed Original ResearchTransgenic mouse modelB cell populationsMouse modelB cellsBone marrowTransgenic micePeripheral bloodPeritoneal cavitySOX11 expressionDouble transgenic mouse modelIncurable B-cell malignancySingle transgenic miceB-cell hyperplasiaB-cell phenotypeWild-type miceCell populationsB-cell malignanciesRole of SOX11Multiple oncogenic pathwaysCyclin D1 overexpressionMCL pathogenesisMCL tumorsExpression of SOX11Key diagnostic featuresMedian survival