2015
SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis
Kuo P, Jiang Z, Perumal D, Leshchenko V, Lagana' A, Katz S, Walensky L, Shaknovich R, Ye B, Parekh S. SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis. Blood 2015, 126: 1253. DOI: 10.1182/blood.v126.23.1253.1253.Peer-Reviewed Original ResearchTransgenic mouse modelB cell populationsMouse modelB cellsBone marrowTransgenic micePeripheral bloodPeritoneal cavitySOX11 expressionDouble transgenic mouse modelIncurable B-cell malignancySingle transgenic miceB-cell hyperplasiaB-cell phenotypeWild-type miceCell populationsB-cell malignanciesRole of SOX11Multiple oncogenic pathwaysCyclin D1 overexpressionMCL pathogenesisMCL tumorsExpression of SOX11Key diagnostic featuresMedian survival
2013
Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells
Katz SG, LaBelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood 2013, 123: 884-893. PMID: 24352880, PMCID: PMC3916879, DOI: 10.1182/blood-2013-04-499079.Peer-Reviewed Original ResearchConceptsMantle cell lymphomaCyclin D1 transgenic miceCyclin D1 overexpressionB cellsCell lymphomaAggressive B-cell lymphomasSubset of miceTransgenic mouse modelB-cell lymphomaDeletion of BimPathogenesis of MCLHuman mantle cell lymphomaDevelopment of MCLStimulation regimensConventional chemotherapyMouse modelLymphoid maturationTransgenic miceLymphomaBIM deletionSelective expansionMiceProapoptotic BimPathogenesisGenetic aberrations