2012
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
Tian Z, Zhao J, Tai Y, Amin S, Hu Y, Berger A, Richardson P, Chauhan D, Anderson K. Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells. Blood 2012, 120: 3958-3967. PMID: 22983447, PMCID: PMC3496955, DOI: 10.1182/blood-2012-01-401794.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBoron CompoundsCell DeathCell Line, TumorCell MovementCell SurvivalCluster AnalysisDrug Resistance, NeoplasmGene Expression ProfilingGene Expression Regulation, NeoplasticGenes, Tumor SuppressorGlycineHumansImidazolesMiceMicroRNAsMultiple MyelomaProto-Oncogene Proteins c-pim-1PyridazinesSignal TransductionXenograft Model Antitumor AssaysConceptsMultiple myelomaMM cellsPim-1Tumor suppressor geneTranscriptional regulationPim-1 overexpressionBiochemical inhibitorsApoptotic signalingRole of miRTumor suppressorMiR33bMM cell viabilityCell deathPatient MM cellsMM xenograft modelNovel therapeutic strategiesLuciferase activityColony formationOverexpressionMiR profilingTumor pathogenesisInvestigational agentsCritical roleRegulationCell viability
2011
The dChip survival analysis module for microarray data
Amin S, Shah P, Yan A, Adamia S, Minvielle S, Avet-Loiseau H, Munshi N, Li C. The dChip survival analysis module for microarray data. BMC Bioinformatics 2011, 12: 72. PMID: 21388547, PMCID: PMC3068974, DOI: 10.1186/1471-2105-12-72.Peer-Reviewed Original ResearchConceptsAnalysis moduleUser-friendly wayDemonstration dataMicroarray data analysisAnalysis functionsFast computationSoftware packageSoftwareSignificant chromosome regionsMicroarray dataMinimal learning curveGene expressionDChip softwareModuleGenome-wide copy number alterationsData analysisSNP array dataSurvival gene signaturesCopy number dataChromosome displayContext of genesUsersCopy number alterationsChromosome regionsClustering