Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2
Song W, Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Li Y, Sperling A, Rashid N, Samur M, Amin S, Tai Y, Hideshima T, Parmigiani G, Magrangeas F, Minvielle S, Avet-Loiseau H, Anderson K, Li C, Munshi N. Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2. Blood 2014, 124: 4714. DOI: 10.1182/blood.v124.21.4714.4714.Peer-Reviewed Original ResearchRNA binding proteinRNA-seq dataAlternative splicingSplicing factorsActin polymerizationCell linesNon-protein coding RNAsIsoform switchBinding proteinDiversity of transcriptomesMM cell linesRNA alternative splicingAlternative splicing eventsImportant RNA binding proteinRNA splicing factorsRNA-seq analysisPredominant nuclear localizationGene enrichment analysisCytoskeleton regulationGene regulationStromal cell interactionsSplicing eventsCoding RNAsQ-PCR analysisImportant genes