Targeting Sp1 Transactivation In Waldenstrom's Macroglobulinemia: a Novel Therapeutic Option
Fulciniti M, Amin S, Mohan V, Yang G, Nanjappa P, Tassone P, Prabhala R, Cheng L, Anderson K, Treon S, Munshi N. Targeting Sp1 Transactivation In Waldenstrom's Macroglobulinemia: a Novel Therapeutic Option. Blood 2010, 116: 120. DOI: 10.1182/blood.v116.21.120.120.Peer-Reviewed Original ResearchBone marrow stromal cellsSp1 activityWM cellsCell growthSp1 protein expressionSp1 protein levelsTranscription factor Sp1Lentiviral shRNA constructsGC-rich motifsCaspase-8 activationImportant transcription factorMitochondrial apoptotic pathwayExpression of genesAnti-apoptotic genesGene promoter regionHigh Sp1 expressionSp1 transactivationLuciferase reporter plasmidFactor Sp1Sp proteinsSp1 inhibitorDownregulation of expressionSp1 expressionTranscription factorsPromoter elementsBiology and Therapeutic Targeting of Sp1 Transactivation In Myeloma
Fulciniti M, Amin S, Nanjappa P, Rodig S, Hideshima T, Pal J, Mohan V, Lee K, Shammas M, Minvielle S, Prabhala R, Avet-Loiseau H, Cheng L, Anderson K, Munshi N. Biology and Therapeutic Targeting of Sp1 Transactivation In Myeloma. Blood 2010, 116: 134. DOI: 10.1182/blood.v116.21.134.134.Peer-Reviewed Original ResearchSp1 activityTranscription factorsCell growthApoptotic pathwayOverexpression of Sp1Role of Sp1GC-rich motifsGene expression profilesMitochondrial apoptotic pathwayPathway inhibitor U0126ERK pathway inhibitor U0126Important regulatory roleSpecific inhibitionSp1 transactivationMAPK genesSp1 siRNAMM cell growthSp1 activationMM cellsCellular processesNuclear localizationDNA bindingSp1Transcriptional activityPromoter activity