Featured Publications
Integrating Gene and Mir Expression Profiles and Regulatory Network Structures to Define Aberrent Feed Forward Loops with Functional and Clinical Implications in Myeloma.
Fulciniti M, Li Y, Wang X, Samur M, Yan Z, Amin S, Li C, Anderson K, Munshi N. Integrating Gene and Mir Expression Profiles and Regulatory Network Structures to Define Aberrent Feed Forward Loops with Functional and Clinical Implications in Myeloma. Blood 2012, 120: 2386. DOI: 10.1182/blood.v120.21.2386.2386.Peer-Reviewed Original ResearchFeed-forward loopRegulatory network structureGene/sGene expressionExpression profilesMiR expression profilesGene expression profile analysisNormal plasma cellsLarge regulatory networkExpression profile analysisOncogenic effectsExpression profile dataMaster TFsNegative feedback regulationRegulatory networksOncogenomic analysisDifferential genesRegulatory loopMolecular impactHeterogeneous genetic backgroundMiRNA expressionFeedback regulationMiR profilesGenetic backgroundMalignant phenotype
2012
Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers
Yan Z, Shah P, Amin S, Samur M, Huang N, Wang X, Misra V, Ji H, Gabuzda D, Li C. Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Research 2012, 40: e135-e135. PMID: 22645320, PMCID: PMC3458521, DOI: 10.1093/nar/gks395.Peer-Reviewed Original ResearchConceptsFeed-forward loopTranscription factorsMiRNA expression profilesExpression profilesNovel feed-forward loopCancer-related transcription factorsExpression dataTF target genesMiRNA-mRNA interactionsCommon target genesMiR-15/miRMiRNA expression dataMiRNA partnersTranscriptome changesTarget genesDifferential genesIntegrative analysisMultiple cancer typesGenesMiRNA expressionHuman cancersLiterature validationBiological conditionsMiRNAsRegulator