Biology and Therapeutic Targeting of Sp1 Transactivation In Myeloma
Fulciniti M, Amin S, Nanjappa P, Rodig S, Hideshima T, Pal J, Mohan V, Lee K, Shammas M, Minvielle S, Prabhala R, Avet-Loiseau H, Cheng L, Anderson K, Munshi N. Biology and Therapeutic Targeting of Sp1 Transactivation In Myeloma. Blood 2010, 116: 134. DOI: 10.1182/blood.v116.21.134.134.Peer-Reviewed Original ResearchSp1 activityTranscription factorsCell growthApoptotic pathwayOverexpression of Sp1Role of Sp1GC-rich motifsGene expression profilesMitochondrial apoptotic pathwayPathway inhibitor U0126ERK pathway inhibitor U0126Important regulatory roleSpecific inhibitionSp1 transactivationMAPK genesSp1 siRNAMM cell growthSp1 activationMM cellsCellular processesNuclear localizationDNA bindingSp1Transcriptional activityPromoter activity