Targeting Sp1 Transactivation In Waldenstrom's Macroglobulinemia: a Novel Therapeutic Option
Fulciniti M, Amin S, Mohan V, Yang G, Nanjappa P, Tassone P, Prabhala R, Cheng L, Anderson K, Treon S, Munshi N. Targeting Sp1 Transactivation In Waldenstrom's Macroglobulinemia: a Novel Therapeutic Option. Blood 2010, 116: 120. DOI: 10.1182/blood.v116.21.120.120.Peer-Reviewed Original ResearchBone marrow stromal cellsSp1 activityWM cellsCell growthSp1 protein expressionSp1 protein levelsTranscription factor Sp1Lentiviral shRNA constructsGC-rich motifsCaspase-8 activationImportant transcription factorMitochondrial apoptotic pathwayExpression of genesAnti-apoptotic genesGene promoter regionHigh Sp1 expressionSp1 transactivationLuciferase reporter plasmidFactor Sp1Sp proteinsSp1 inhibitorDownregulation of expressionSp1 expressionTranscription factorsPromoter elements