2014
Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2
Song W, Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Li Y, Sperling A, Rashid N, Samur M, Amin S, Tai Y, Hideshima T, Parmigiani G, Magrangeas F, Minvielle S, Avet-Loiseau H, Anderson K, Li C, Munshi N. Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2. Blood 2014, 124: 4714. DOI: 10.1182/blood.v124.21.4714.4714.Peer-Reviewed Original ResearchRNA binding proteinRNA-seq dataAlternative splicingSplicing factorsActin polymerizationCell linesNon-protein coding RNAsIsoform switchBinding proteinDiversity of transcriptomesMM cell linesRNA alternative splicingAlternative splicing eventsImportant RNA binding proteinRNA splicing factorsRNA-seq analysisPredominant nuclear localizationGene enrichment analysisCytoskeleton regulationGene regulationStromal cell interactionsSplicing eventsCoding RNAsQ-PCR analysisImportant genes
2013
Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells
Song W, Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Amin S, Tai Y, Li Y, Sperling A, Rashid N, Magrangeas F, Minvielle S, Avet-Loiseau H, Anderson K, Li C, Munshi N. Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells. Blood 2013, 122: 3085. DOI: 10.1182/blood.v122.21.3085.3085.Peer-Reviewed Original ResearchAlternate splicingActin polymerizationCell linesRPMI8226 cell lineMM cell linesAlternative splicing regulatorsImportant splicing factorsAlternative splicing eventsGeneChip Human Exon 1.0 ST ArrayHuman Exon 1.0 ST ArrayPredominant nuclear localizationRNA-seq dataExpression levelsIGF-1 stimulationPost-translational changesGene expression levelsSplicing regulatorsGene functionStromal cell interactionsRNA splicingSplicing eventsSplicing factorsAlternative splicingRNA-seqMolecular roleTranscription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
Wang X, Yan Z, Fulciniti M, Li Y, Gkotzamanidou M, Amin S, Shah P, Zhang Y, Munshi N, Li C. Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma. Leukemia 2013, 28: 894-903. PMID: 23925045, PMCID: PMC4155324, DOI: 10.1038/leu.2013.233.Peer-Reviewed Original ResearchConceptsCell cycle arrestCycle arrestCoexpression analysisCell cycle arrest genesHyperdiploid MMCell cycle arrest pathwaysNon-hyperdiploid multiple myelomaDistinct chromosomal alterationsMyeloma subtypeMultiple myelomaTranscription factorsArrest pathwaysSp1Low coexpressionProper regulationHuman cancersDifferent survival outcomesChromosomal alterationsPlasma B cellsCoexpressionCell linesNovel hypothesisSurvival outcomesMyeloma proliferationClinical utility