Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy
Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M. Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy. Genes & Development 2016, 30: 1881-1894. PMID: 27585592, PMCID: PMC5024685, DOI: 10.1101/gad.282194.116.Peer-Reviewed Original ResearchConceptsSUMO protease Ulp2Small ubiquitin-related modifierPost-translational protein modificationWhole-genome RNA sequencingNumerous cellular pathwaysG1 phase cyclinsGenome maintenanceChromosome IUlp2Particular chromosomeAdapts cellsCell divisionSUMO proteaseCellular stressRNA sequencingProtein modificationCellular pathwaysNormal copy numberTranscript levelsMost human tumorsCopy numberRapid adaptationExtra copiesChromosomesSpecific aneuploidies