Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver
Payabvash S, Beheshtian A, Salmasi AH, Kiumehr S, Ghahremani MH, Tavangar SM, Sabzevari O, Dehpour AR. Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver. Life Sciences 2006, 79: 972-980. PMID: 16750225, DOI: 10.1016/j.lfs.2006.05.008.Peer-Reviewed Original ResearchConceptsChronic morphine treatmentMorphine treatmentMorphine administrationHigh dosesInduction of apoptosisInduction of liverHepatic glutathione concentrationAntioxidant defenseLiver antioxidant defensesObserved adverse effectsPro-oxidant effectsCancer painEnzymatic antioxidant defensesOpioid analgesicsChronic painOpioid drugsTumor spreadOpioid receptorsSame dosesHepatotoxic effectsProtective roleTumor growthLow dosesMorphineHepatocyte apoptosis