2024
Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessment
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionEarly brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
Bobba P, Weber C, Malhotra A, Bahtiyar M, Copel J, Taylor S, Ment L, Payabvash S. Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally. Scientific Reports 2023, 13: 21514. PMID: 38057452, PMCID: PMC10700578, DOI: 10.1038/s41598-023-48963-z.Peer-Reviewed Original ResearchUtility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently
Andrijauskis D, Woolf G, Kuehne A, Al-Dasuqi K, Silva C, Payabvash S, Malhotra A. Utility of Gadolinium-Based Contrast in Initial Evaluation of Seizures in Children Presenting Emergently. American Journal Of Neuroradiology 2023, 44: 1208-1211. PMID: 37652579, PMCID: PMC10549952, DOI: 10.3174/ajnr.a7976.Peer-Reviewed Original ResearchConceptsSeizure presentationMR imagingConsecutive pediatric patientsNew-onset seizuresEvaluation of seizuresIschemic/hypoxicImaging of patientsBrain MR imagingGadolinium-based contrast agentsNoncontrast studyAcute onsetHippocampal sclerosisPediatric seizuresPatient agePediatric patientsNormal findingsIntracranial hemorrhageEmergency departmentVascular anomaliesInpatient unitGadolinium contrastPatientsNeurodevelopmental lesionAdditive benefitSeizuresImpact of postnatal weight gain on brain white matter maturation in very preterm infants
Bobba P, Weber C, Higaki A, Mukherjee P, Scheinost D, Constable R, Ment L, Taylor S, Payabvash S. Impact of postnatal weight gain on brain white matter maturation in very preterm infants. Journal Of Neuroimaging 2023, 33: 991-1002. PMID: 37483073, PMCID: PMC10800683, DOI: 10.1111/jon.13145.Peer-Reviewed Original ResearchConceptsBirth weight z-scoreMagnetic resonance imagingVery preterm infantsPostnatal weight gainWeight z-scoreWhite matter maturationBirth weightDiffusion tensor imagingNeurological outcomePreterm infantsGestational ageWeight gainCorpus callosumHigher birth weight z-scoresBrain white matter maturationLong-term neurological deficitsZ-scoreBrain developmentWeight z-score changeWM tractsZ-score changeWM maturationWeeks of lifeNeurological deficitsNutritional interventionIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexAssociation of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018
Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexWaist circumferenceBMI z-scoreCross-sectional studyBrain healthCross-sectional analysisFunctional connectivityMass indexMean ageInterval developmentCorpus callosumAssociation of BMIHigher baseline body mass indexBaseline cross-sectional analysisBaseline body mass indexBrain integrityResting-state functional connectivityLongitudinal analysisFuture treatment trialsABCD studyLower microstructural integrityCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyCardiovascular implicationsBlood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults
Acosta J, Haider S, Rivier C, Leasure A, Sheth K, Falcone G, Payabvash S. Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults. Stroke And Vascular Neurology 2023, 8: 358-367. PMID: 36878613, PMCID: PMC10647862, DOI: 10.1136/svn-2022-001929.Peer-Reviewed Original Research
2022
Brain injury patterns in hypoxic ischemic encephalopathy of term neonates
Bobba PS, Malhotra A, Sheth KN, Taylor SN, Ment LR, Payabvash S. Brain injury patterns in hypoxic ischemic encephalopathy of term neonates. Journal Of Neuroimaging 2022, 33: 79-84. PMID: 36164277, DOI: 10.1111/jon.13052.Peer-Reviewed Original ResearchConceptsSevere hypoxic-ischemic encephalopathyHypoxic-ischemic encephalopathyHypoxic-ischemic lesionsSeverity of HIEModerate hypoxic-ischemic encephalopathyTerm neonatesIschemic lesionsDiffusion-weighted imagingBasal gangliaDiagnosis of HIESeverity categoriesBrain injury patternsDeep white matterMRI diffusion-weighted imagingT2-weighted imagesPresence of lesionsVoxel-wise analysisRespiration (APGAR) scoreInfarct volumeStandard brain spaceIschemic encephalopathyInjury patternsBrain injuryLentiform nucleusLesion volumeAge‐related topographic map of magnetic resonance diffusion metrics in neonatal brains
Bobba PS, Weber CF, Mak A, Mozayan A, Malhotra A, Sheth KN, Taylor SN, Vossough A, Grant PE, Scheinost D, Constable RT, Ment LR, Payabvash S. Age‐related topographic map of magnetic resonance diffusion metrics in neonatal brains. Human Brain Mapping 2022, 43: 4326-4334. PMID: 35599634, PMCID: PMC9435001, DOI: 10.1002/hbm.25956.Peer-Reviewed Original ResearchConceptsGestational ageCerebellar white matterWhite matterNeonatal brainDiffusion-weighted imagingCorpus callosumMD valuesCorpus callosum myelinationLower gestational ageTerm-equivalent ageSubcortical white matterFA/MDApparent diffusion coefficient (ADC) valuesMonths of ageDiffusion tensor imaging (DTI) metricsDiffusion metricsAge-related evolutionAge-related changesAge-specific normative valuesNeonatal ageBrain parenchymaCorticospinal tractNeonate brainDiffusivity metricsADC valuesBedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest
Beekman R, Crawford A, Mazurek MH, Prabhat AM, Chavva IR, Parasuram N, Kim N, Kim JA, Petersen N, de Havenon A, Khosla A, Honiden S, Miller PE, Wira C, Daley J, Payabvash S, Greer DM, Gilmore EJ, Kimberly W, Sheth KN. Bedside monitoring of hypoxic ischemic brain injury using low-field, portable brain magnetic resonance imaging after cardiac arrest. Resuscitation 2022, 176: 150-158. PMID: 35562094, PMCID: PMC9746653, DOI: 10.1016/j.resuscitation.2022.05.002.Peer-Reviewed Original ResearchConceptsCardiac arrestBrain injuryHypoxic-ischemic brain injuryAdverse neurological outcomesIschemic brain injurySingle-center studyBrain magnetic resonanceBrain injury severityBoard-certified neuroradiologistsLow-field MRIFLAIR signal intensityNeurological outcomeCA patientsIll patientsMRI findingsCA survivorsCenter studyMRI examinationsClinical careHigh riskInjury severityPatientsSignal intensityBedside monitoringMR imagingAnalysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia
Acosta JN, Both CP, Rivier C, Szejko N, Leasure AC, Gill TM, Payabvash S, Sheth KN, Falcone GJ. Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia. JAMA Network Open 2022, 5: e2215328. PMID: 35622359, PMCID: PMC9142873, DOI: 10.1001/jamanetworkopen.2022.15328.Peer-Reviewed Original ResearchConceptsBrain healthBrain volumeMagnetic resonance imagingLower mean volumeLifestyle factorsCardiovascular healthLarge population-based cohort studyLife's Simple 7 (LS7) scoresPopulation-based cohort studyBrain magnetic resonance imagingMean volumeWhite matter hyperintensity volumeBrain health benefitsCommunity-dwelling personsImproved brain healthOutcomes of interestUK BiobankFinal analytical sampleAsymptomatic personsCohort studyLS7 scoreNeuroimaging markerHyperintensity volumeMAIN OUTCOMEGenetic predispositionBedside detection of intracranial midline shift using portable magnetic resonance imaging
Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.Peer-Reviewed Original ResearchConceptsMidline shiftNeuroscience intensive care unitCare measurementYale-New Haven HospitalValuable bedside toolIntensive care unitPoor clinical outcomeBrain-injured patientsMass effectNew Haven HospitalMagnetic resonance imagingClinical outcomesIll patientsCare unitStroke patientsFunctional outcomeBedside toolObservational studyBedside detectionImaging examsPatientsResonance imagingPortable MRIImaging suiteSignificant concordance
2019
White Matter Connectome Edge Density in Children with Autism Spectrum Disorders: Potential Imaging Biomarkers Using Machine-Learning Models
Payabvash S, Palacios E, Owen JP, Wang MB, Tavassoli T, Gerdes M, Brandes-Aitken A, Cuneo D, Marco E, Mukherjee P. White Matter Connectome Edge Density in Children with Autism Spectrum Disorders: Potential Imaging Biomarkers Using Machine-Learning Models. Brain Connectivity 2019, 9: 209-220. PMID: 30661372, PMCID: PMC6444925, DOI: 10.1089/brain.2018.0658.Peer-Reviewed Original Research
2017
Multivariate Prognostic Model of Acute Stroke Combining Admission Infarct Location and Symptom Severity: A Proof-of-Concept Study
Payabvash S, Benson JC, Tyan AE, Taleb S, McKinney AM. Multivariate Prognostic Model of Acute Stroke Combining Admission Infarct Location and Symptom Severity: A Proof-of-Concept Study. Journal Of Stroke And Cerebrovascular Diseases 2017, 27: 936-944. PMID: 29198948, DOI: 10.1016/j.jstrokecerebrovasdis.2017.10.034.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveBrainBrain IschemiaBrain MappingDatabases, FactualDecision Support TechniquesDiffusion Magnetic Resonance ImagingDisability EvaluationFemaleHumansLogistic ModelsMaleMesencephalonMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPonsPredictive Value of TestsProof of Concept StudyReproducibility of ResultsRetrospective StudiesRisk FactorsROC CurveSeverity of Illness IndexStrokeTime FactorsTreatment OutcomeConceptsDisability/deathMidbrain/ponsAcute ischemic stroke patientsIschemic stroke patientsAdmission NIHSS scoreStroke patientsNIHSS scoreIndependent predictorsInfarct locationScale scoreHealth Stroke Scale scoreHigher admission NIHSS scoresModified Rankin Scale scoreSymptom severityAdmission stroke severityBaseline functional disabilityLarger infarct volumesStroke Scale scoreRankin Scale scoreHours of onsetAcute ischemic infarctMultivariate prognostic modelMajor arterial occlusionHypothesis-generating studyVoxel-based analysisCerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis
Payabvash S, Taleb S, Qureshi AI. Cerebral regions preserved by successful endovascular recanalization of acute M1 segment occlusions: a voxel based analysis. British Journal Of Radiology 2017, 90: 20160869. PMID: 28165757, PMCID: PMC5605076, DOI: 10.1259/bjr.20160869.Peer-Reviewed Original ResearchConceptsM1 segment occlusionDisability/deathSuccessful endovascular recanalizationVoxel-based analysisFinal infarct volumeSuccessful recanalizationSegment occlusionInfarct volumeFavorable outcomePrecentral gyrusCerebral regionsEndovascular recanalizationEndovascular treatmentInsular ribbonSmaller final infarct volumesDays post-symptom onsetMiddle cerebral artery M1 segmentModified Rankin Scale scoreCerebral Infarction scoreTimely reperfusion treatmentEarly clinical outcomesHigh ratePost-symptom onsetSmaller infarct volumesRankin Scale score
2016
Topographic Assessment of Acute Ischemic Changes for Prognostication of Anterior Circulation Stroke
Payabvash S, Noorbaloochi S, Qureshi AI. Topographic Assessment of Acute Ischemic Changes for Prognostication of Anterior Circulation Stroke. Journal Of Neuroimaging 2016, 27: 227-231. PMID: 27593522, DOI: 10.1111/jon.12383.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScoreDisability/deathAnterior circulation strokeAcute ischemic changesSymptomatic intracranial hemorrhageIntracranial hemorrhageIschemic changesIndependent predictorsFavorable outcomeIntravenous thrombolytic therapyCT/MRI scansRankin Scale scoreEarly ischemic changesAcute ischemic infarctTopographic assessmentIschemic infarctAdmission CTClinical outcomesStroke patientsThrombolytic therapyCT scoreLentiform nucleusTomography scanImproved outcomesPrognostic toolClinical implications of eye deviation on admission CT examination of acute ischaemic stroke patients
Payabvash S, Qureshi I, Qureshi AI. Clinical implications of eye deviation on admission CT examination of acute ischaemic stroke patients. Clinical Radiology 2016, 71: 1314.e11-1314.e15. PMID: 27592397, DOI: 10.1016/j.crad.2016.08.002.Peer-Reviewed Original ResearchConceptsAlberta Stroke Program Early CT ScoreAcute ischemic stroke patientsIschemic stroke patientsHigher admission NIHSS scoresAdmission NIHSS scoreEye deviationStroke patientsNIHSS scoreHaemorrhagic transformationCT examinationsLow Alberta Stroke Program Early CT ScoreScale scoreHealth Stroke Scale scoreOlder ageAdmission CT examinationAdmission National InstitutesPatients' older ageStroke Scale scoreHigh rateRankin Scale scoreInfarct volumeMRS scoreAdmission CTCT scorePrognostic value
2015
Detection of Intraparenchymal Hemorrhage After Endovascular Therapy in Patients with Acute Ischemic Stroke Using Immediate Postprocedural Flat‐Panel Computed Tomography Scan
Payabvash S, Khan AA, Qureshi MH, Saeed O, Suri MF, Qureshi AI. Detection of Intraparenchymal Hemorrhage After Endovascular Therapy in Patients with Acute Ischemic Stroke Using Immediate Postprocedural Flat‐Panel Computed Tomography Scan. Journal Of Neuroimaging 2015, 26: 213-218. PMID: 26282065, DOI: 10.1111/jon.12277.Peer-Reviewed Original ResearchConceptsMultidetector CT studiesNegative predictive valueIschemic stroke patientsIntraparenchymal hemorrhageCT scanEndovascular treatmentHyperdense lesionParenchymal lesionsStroke patientsPredictive valueCT studiesMultidetector CTAcute ischemic stroke patientsAcute ischemic strokeAcute stroke patientsMultidetector CT scanPositive predictive valueEndovascular therapyIschemic strokePost procedureTomography scanSeparate cohortSuch lesionsPatientsDiagnostic valueAcute CT perfusion changes in seizure patients presenting to the emergency department with stroke-like symptoms: correlation with clinical and electroencephalography findings
Payabvash S, Oswood MC, Truwit CL, McKinney AM. Acute CT perfusion changes in seizure patients presenting to the emergency department with stroke-like symptoms: correlation with clinical and electroencephalography findings. Clinical Radiology 2015, 70: 1136-1143. PMID: 26155937, DOI: 10.1016/j.crad.2015.06.078.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowRelative mean transit timeStroke-like symptomsSeizure patientsPerfusion changesClinical presentationEmergency departmentCTP examinationAcute stroke-like presentationAcute stroke-like symptomsNon-focal neurological deficitsSpeech deficitsStroke-like presentationSubset of patientsDifferent clinical presentationsCerebral blood flowEloquent brain regionsAdmission CTPElectroencephalography findingsNeurological deficitsSymptom onsetSuch patientsEarly followEEG findingsUnilateral motor