2019
Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans
Payabvash S, Falcone GJ, Sze GK, Jain A, Beslow LA, Petersen NH, Sheth KN, Kimberly WT. Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans. Journal Of Stroke And Cerebrovascular Diseases 2019, 29: 104488. PMID: 31787498, PMCID: PMC8820410, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104488.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAgedAnterior Cerebral ArteryCerebrovascular CirculationCerebrumClinical Trials as TopicClinical Trials, Phase II as TopicDiffusion Magnetic Resonance ImagingDisability EvaluationExtremitiesFemaleGlyburideHumansHypoglycemic AgentsInfarction, Anterior Cerebral ArteryInfarction, Middle Cerebral ArteryMaleMiddle AgedMiddle Cerebral ArteryPatient AdmissionPredictive Value of TestsRecovery of FunctionRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsLarge hemispheric infarctionInfarct volumeIndependent predictorsInfarct lesionsHemispheric infarctionHealth Stroke Scale total scorePost-stroke day 3Anterior cerebral artery territoryTotal scoreLeft MCA infarctLeg motor functionNIHSS total scoreHours of onsetOnly independent predictorPoor functional outcomeBorder zoneScale total scoreAnterior extensionMultivariate regression analysisVoxel-wise analysisLHI patientsAdmission NIHSSArtery territoryGlibenclamide treatmentMCA infarct
2017
Multivariate Prognostic Model of Acute Stroke Combining Admission Infarct Location and Symptom Severity: A Proof-of-Concept Study
Payabvash S, Benson JC, Tyan AE, Taleb S, McKinney AM. Multivariate Prognostic Model of Acute Stroke Combining Admission Infarct Location and Symptom Severity: A Proof-of-Concept Study. Journal Of Stroke And Cerebrovascular Diseases 2017, 27: 936-944. PMID: 29198948, DOI: 10.1016/j.jstrokecerebrovasdis.2017.10.034.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overArea Under CurveBrainBrain IschemiaBrain MappingDatabases, FactualDecision Support TechniquesDiffusion Magnetic Resonance ImagingDisability EvaluationFemaleHumansLogistic ModelsMaleMesencephalonMiddle AgedMultivariate AnalysisOdds RatioPatient AdmissionPonsPredictive Value of TestsProof of Concept StudyReproducibility of ResultsRetrospective StudiesRisk FactorsROC CurveSeverity of Illness IndexStrokeTime FactorsTreatment OutcomeConceptsDisability/deathMidbrain/ponsAcute ischemic stroke patientsIschemic stroke patientsAdmission NIHSS scoreStroke patientsNIHSS scoreIndependent predictorsInfarct locationScale scoreHealth Stroke Scale scoreHigher admission NIHSS scoresModified Rankin Scale scoreSymptom severityAdmission stroke severityBaseline functional disabilityLarger infarct volumesStroke Scale scoreRankin Scale scoreHours of onsetAcute ischemic infarctMultivariate prognostic modelMajor arterial occlusionHypothesis-generating studyVoxel-based analysis
2016
The Effects of DWI‐Infarct Lesion Volume on DWI‐FLAIR Mismatch: Is There a Need for Size Stratification?
Payabvash S, Taleb S, Benson JC, Rykken JB, Oswood MC, McKinney AM, Hoffman B. The Effects of DWI‐Infarct Lesion Volume on DWI‐FLAIR Mismatch: Is There a Need for Size Stratification? Journal Of Neuroimaging 2016, 27: 392-396. PMID: 27878926, DOI: 10.1111/jon.12407.Peer-Reviewed Original ResearchConceptsDWI-FLAIR mismatchPositive predictive valueDWI lesion volumeLesion volumeNegative predictive valueStroke onsetAcute infarctsStroke patientsInfarct lesionsPredictive valueFluid-attenuated inversion recovery hyperintensityAcute ischemic stroke patientsInfarct lesion volumeIschemic stroke patientsHours of onsetInversion recovery hyperintensityContralateral normal sideIdentification of strokePotential imaging biomarkerMultivariate regression analysisIdentification of infarctionSymptom onsetTherapy timeNormal sideImaging biomarkers
2012
Location-weighted CTP analysis predicts early motor improvement in stroke
Payabvash S, Souza LC, Kamalian S, Wang Y, Passanese J, Kamalian S, Fung SH, Halpern EF, Schaefer PW, Gonzalez RG, Furie KL, Lev MH. Location-weighted CTP analysis predicts early motor improvement in stroke. Neurology 2012, 78: 1853-1859. PMID: 22573641, PMCID: PMC3369521, DOI: 10.1212/wnl.0b013e318258f799.Peer-Reviewed Original ResearchConceptsAcute stroke patientsAdmission NIHSSMotor improvementStroke patientsCT perfusionPredictive valueOnly independent clinical predictorMultivariate binary logistic regressionFrontal lobe white matterMultivariate modelIndependent clinical predictorsMotor functional improvementMotor function improvementNegative predictive valuePositive predictive valueSuperior temporal gyrusBinary logistic regressionExtremity paresisAcute strokeSymptom onsetClinical predictorsConsecutive patientsIndependent predictorsClinical outcomesImaging predictors
2011
CT Cerebral Blood Flow Maps Optimally Correlate With Admission Diffusion-Weighted Imaging in Acute Stroke but Thresholds Vary by Postprocessing Platform
Kamalian S, Kamalian S, Maas MB, Goldmacher GV, Payabvash S, Akbar A, Schaefer PW, Furie KL, Gonzalez RG, Lev MH. CT Cerebral Blood Flow Maps Optimally Correlate With Admission Diffusion-Weighted Imaging in Acute Stroke but Thresholds Vary by Postprocessing Platform. Stroke 2011, 42: 1923-1928. PMID: 21546490, PMCID: PMC3125441, DOI: 10.1161/strokeaha.110.610618.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingCT perfusion parametersAcute strokeCT perfusionInfarct coreAdmission diffusion-weighted imagingPerfusion parametersCerebral blood flowCerebral blood flow mapsCerebral blood volumeCharacteristic curve analysisAdmission CT perfusionBlood flow mapsUninvolved hemisphere
2005
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sciences 2005, 76: 2497-2512. PMID: 15763080, DOI: 10.1016/j.lfs.2004.12.009.Peer-Reviewed Original ResearchConceptsBile duct ligationChronic L-NAME treatmentL-NAME treatmentPlasma Hcy concentrationPlasma HcyDuct ligationBiliary cirrhosisBDL ratsHcy concentrationsSAH ratioNitric oxideSecondary biliary cirrhosisWeeks of cholestasisImpaired liver functionModel of cirrhosisHcy elevationMethionine overloadPrecirrhotic stageSubsequent cirrhosisLiver functionObstructive cholestasisHepatic fibrogenesisHcy metabolismUnoperated ratsCholestasis