2024
Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial
Charalambous S, Maraba N, Jennings L, Rabothata I, Cogill D, Mukora R, Hippner P, Naidoo P, Xaba N, Mchunu L, Velen K, Orrell C, Fielding K. Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial. EClinicalMedicine 2024, 75: 102745. PMID: 39170937, PMCID: PMC11338121, DOI: 10.1016/j.eclinm.2024.102745.Peer-Reviewed Original ResearchEvidence of improved adherenceTreatment adherencePrimary health clinicsCluster randomised trialCluster randomized trialStandard of careDifferentiated care approachesPoor treatment adherenceMedical monitoringCare approachHealth clinicsAdherence reportsLower treatment completionCluster designDrug-susceptible tuberculosisPrimary outcomeRandomised trialsDrug-sensitive tuberculosisAdherenceTreatment completionCareParticipantsSouth AfricaRandomized trialsFollow-up
2023
Transitional community adherence support for people leaving incarceration in South Africa: a pragmatic, open-label, randomised controlled trial
Mabuto T, Woznica D, Ndini P, Moyo D, Abraham M, Hanrahan C, Charalambous S, Zack B, Baral S, Owczarzak J, Hoffmann C. Transitional community adherence support for people leaving incarceration in South Africa: a pragmatic, open-label, randomised controlled trial. The Lancet HIV 2023, 11: e11-e19. PMID: 38071994, PMCID: PMC10894448, DOI: 10.1016/s2352-3018(23)00235-7.Peer-Reviewed Original ResearchConceptsHIV treatment servicesUsual care groupTreatment servicesAntiretroviral therapyPrimary outcomeCare groupSouth African National Clinical Trials RegisterDifferentiated service delivery modelsClinical Trials RegisterPeer-led interventionsPassive referralAdherence supportTrials RegisterUsual careAdherence clubsAdverse eventsTreat analysisHIV treatmentMultifactorial barriersCorrectional facilitiesService delivery modelsFinal analysisMental healthMonthsNational InstituteImpact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program
Tollefson D, Dasgupta S, Setswe G, Reeves S, Charalambous S, Duerr A. Impact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program. PLOS ONE 2023, 18: e0294719. PMID: 38033029, PMCID: PMC10688901, DOI: 10.1371/journal.pone.0294719.Peer-Reviewed Original ResearchConceptsHIV service deliveryHIV testingTreatment initiationIntervention facilitiesHealth workersYoung adultsAdolescents/young adultsProportion of patientsPragmatic clusterSecondary outcomesHIV positivityPrimary outcomeTreat analysisHIV servicesHIV programsHealth facilitiesHIVBaseline outcomesTrialsService deliveryNull trialsCareImmediate increaseOutcomesGreater improvement