2024
Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial
Charalambous S, Maraba N, Jennings L, Rabothata I, Cogill D, Mukora R, Hippner P, Naidoo P, Xaba N, Mchunu L, Velen K, Orrell C, Fielding K. Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial. EClinicalMedicine 2024, 75: 102745. PMID: 39170937, PMCID: PMC11338121, DOI: 10.1016/j.eclinm.2024.102745.Peer-Reviewed Original ResearchEvidence of improved adherenceTreatment adherencePrimary health clinicsCluster randomised trialCluster randomized trialStandard of careDifferentiated care approachesPoor treatment adherenceMedical monitoringCare approachHealth clinicsAdherence reportsLower treatment completionCluster designDrug-susceptible tuberculosisPrimary outcomeRandomised trialsDrug-sensitive tuberculosisAdherenceTreatment completionCareParticipantsSouth AfricaRandomized trialsFollow-up
2023
“It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives
Munedzimwe F, Chetty-Makkan C, Mukora R, Charalambous S, Turner K, Chihota V. “It’s about time they taught us”: a qualitative study evaluating the barriers to finding and screening child contacts under five at risk for TB in Gauteng Province, South Africa from the provider and caregiver perspectives. BMC Health Services Research 2023, 23: 1415. PMID: 38102646, PMCID: PMC10722712, DOI: 10.1186/s12913-023-10359-0.Peer-Reviewed Original ResearchConceptsTB preventive treatmentTB prevention strategiesIsoniazid preventive therapyTB staffSemi-structured questionnaireTB transmissionFacility staffPrevention strategiesPrimary health clinicsPrevention of tuberculosisEnd TB goalChild contactsYears of ageFacility observationsSemi-structured interview guidePreventive therapyTB preventionTB screeningTB treatmentPreventive servicesPreventive treatmentEkurhuleni DistrictHealth clinicsHigh riskCaregiver perspectives