2024
Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial
Charalambous S, Maraba N, Jennings L, Rabothata I, Cogill D, Mukora R, Hippner P, Naidoo P, Xaba N, Mchunu L, Velen K, Orrell C, Fielding K. Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial. EClinicalMedicine 2024, 75: 102745. PMID: 39170937, PMCID: PMC11338121, DOI: 10.1016/j.eclinm.2024.102745.Peer-Reviewed Original ResearchEvidence of improved adherenceTreatment adherencePrimary health clinicsCluster randomised trialCluster randomized trialStandard of careDifferentiated care approachesPoor treatment adherenceMedical monitoringCare approachHealth clinicsAdherence reportsLower treatment completionCluster designDrug-susceptible tuberculosisPrimary outcomeRandomised trialsDrug-sensitive tuberculosisAdherenceTreatment completionCareParticipantsSouth AfricaRandomized trialsFollow-upA pilot cross-sectional study of non-communicable diseases in TB household contacts
Hamada Y, Lugendo A, Ntshiqa T, Kubeka G, Lalashowi J, Mwastaula S, Ntshamane K, Sabi I, Wilson S, Copas A, Velen K, Ntinginya N, Minja L, Abubakar I, Charalambous S, Rangaka M. A pilot cross-sectional study of non-communicable diseases in TB household contacts. IJTLD OPEN 2024, 1: 154-159. PMID: 38988408, PMCID: PMC11231826, DOI: 10.5588/ijtldopen.23.0579.Peer-Reviewed Original ResearchNon-communicable diseasesTB household contactsNon-communicable disease screeningStudy of non-communicable diseasePrevalence of non-communicable diseasesPilot cross-sectional studyContact investigationCross-sectional studyIntegrated screeningHousehold contactsHemoglobin A1cNeighborhood householdsPrevalenceBlood pressureBlood glucoseSouth AfricaAdult contactsScreeningCareNeighborhoodIndividualsA1cDiabetesDiseasePilot
2023
Impact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program
Tollefson D, Dasgupta S, Setswe G, Reeves S, Charalambous S, Duerr A. Impact of youth lay health workers on HIV service delivery in South Africa: A pragmatic cluster randomized trial of the Youth Health Africa program. PLOS ONE 2023, 18: e0294719. PMID: 38033029, PMCID: PMC10688901, DOI: 10.1371/journal.pone.0294719.Peer-Reviewed Original ResearchConceptsHIV service deliveryHIV testingTreatment initiationIntervention facilitiesHealth workersYoung adultsAdolescents/young adultsProportion of patientsPragmatic clusterSecondary outcomesHIV positivityPrimary outcomeTreat analysisHIV servicesHIV programsHealth facilitiesHIVBaseline outcomesTrialsService deliveryNull trialsCareImmediate increaseOutcomesGreater improvement