2024
Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.
Wallis R, Sabi I, Lalashowi J, Bakuli A, Mapamba D, Olomi W, Siyame E, Ngaraguza B, Chimbe O, Charalambous S, Rachow A, Ivanova O, Zurba L, Myombe B, Kunambi R, Hoelscher M, Ntinginya N, Churchyard G. Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis. NEJM Evidence 2024, 3: evidoa2300332. PMID: 39189858, DOI: 10.1056/evidoa2300332.Peer-Reviewed Original ResearchConceptsWhole blood glutathione levelsLung functionN-acetylcysteinePulmonary tuberculosisCulture conversionSecondary outcomesGlutathione levelsEffect of N-acetylcysteineTuberculosis treatment outcomesOutcome of lung functionOral N-acetylcysteineRecovery of lung functionAdjunctive N-acetylcysteineAssociated with improved recoveryN-acetylcysteine treatmentPermanent lung injuryFar-advanced tuberculosisSputum cultureStandard therapyNAC administrationAdverse eventsLung injuryGlobal health concernCohort studyClinical evaluation
2023
Transitional community adherence support for people leaving incarceration in South Africa: a pragmatic, open-label, randomised controlled trial
Mabuto T, Woznica D, Ndini P, Moyo D, Abraham M, Hanrahan C, Charalambous S, Zack B, Baral S, Owczarzak J, Hoffmann C. Transitional community adherence support for people leaving incarceration in South Africa: a pragmatic, open-label, randomised controlled trial. The Lancet HIV 2023, 11: e11-e19. PMID: 38071994, PMCID: PMC10894448, DOI: 10.1016/s2352-3018(23)00235-7.Peer-Reviewed Original ResearchConceptsHIV treatment servicesUsual care groupTreatment servicesAntiretroviral therapyPrimary outcomeCare groupSouth African National Clinical Trials RegisterDifferentiated service delivery modelsClinical Trials RegisterPeer-led interventionsPassive referralAdherence supportTrials RegisterUsual careAdherence clubsAdverse eventsTreat analysisHIV treatmentMultifactorial barriersCorrectional facilitiesService delivery modelsFinal analysisMental healthMonthsNational Institute