Salome Charalambous
Associate Professor AdjunctCards
About
Research
Publications
2024
Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis
Holtgrewe L, Johnson A, Nyhan K, Boffa J, Shenoi S, Karat A, Davis J, Charalambous S. Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis. PLOS Global Public Health 2024, 4: e0003753. PMID: 39361564, PMCID: PMC11449336, DOI: 10.1371/journal.pgph.0003753.Peer-Reviewed Original ResearchLatent TB infection prevalenceLatent TB infectionUnderserved populationsTB prevalenceMeta-analysisSystematic reviewNational averagePrevalence of TB diseaseCalculate prevalence ratiosTB diseaseCase-finding strategiesPopulation of personsAssessed study qualityHigh TB prevalenceHigh-burden countriesBurden of tuberculosisTB interventionsPrevalence ratiosStudy qualityReduce tuberculosisHIV statusActive TB diseaseGeneral populationModerate heterogeneityTB incidenceAdjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.
Wallis R, Sabi I, Lalashowi J, Bakuli A, Mapamba D, Olomi W, Siyame E, Ngaraguza B, Chimbe O, Charalambous S, Rachow A, Ivanova O, Zurba L, Myombe B, Kunambi R, Hoelscher M, Ntinginya N, Churchyard G. Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis. NEJM Evidence 2024, 3: evidoa2300332. PMID: 39189858, DOI: 10.1056/evidoa2300332.Peer-Reviewed Original ResearchConceptsWhole blood glutathione levelsLung functionN-acetylcysteinePulmonary tuberculosisCulture conversionSecondary outcomesGlutathione levelsEffect of N-acetylcysteineTuberculosis treatment outcomesOutcome of lung functionOral N-acetylcysteineRecovery of lung functionAdjunctive N-acetylcysteineAssociated with improved recoveryN-acetylcysteine treatmentPermanent lung injuryFar-advanced tuberculosisSputum cultureStandard therapyNAC administrationAdverse eventsLung injuryGlobal health concernCohort studyClinical evaluationUsing mHealth Technologies for Case Finding in Tuberculosis and Other Infectious Diseases in Africa: Systematic Review
Mudzengi D, Chomutare H, Nagudi J, Ntshiqa T, Davis J, Charalambous S, Velen K. Using mHealth Technologies for Case Finding in Tuberculosis and Other Infectious Diseases in Africa: Systematic Review. JMIR MHealth And UHealth 2024, 12: e53211. PMID: 39186366, PMCID: PMC11384173, DOI: 10.2196/53211.Peer-Reviewed Original ResearchHealth-seeking behaviour and patient-related factors associated with the time to TB treatment initiation in four African countries: a cross-sectional survey
Sathar F, Charalambous S, Velen K, Fielding K, Rachow A, Ivanova O, Rassool M, Lalashowi J, Owolabi O, Nhassengo P, Chihota V, Evans D. Health-seeking behaviour and patient-related factors associated with the time to TB treatment initiation in four African countries: a cross-sectional survey. BMJ Public Health 2024, 2: e001002. DOI: 10.1136/bmjph-2024-001002.Peer-Reviewed Original ResearchTB treatment initiationCross-sectional surveyTB symptomsPrimary care facilitiesTreatment initiationMedian total delayHealth-seeking behaviorNational TB Control ProgrammeTB treatmentCohort of adultsTB control programmesActive case findingPatient-related factorsHealth facilitiesTB servicesHIV prevalenceCare facilitiesDrug-susceptible pulmonary TBTotal delaySecond-leading causeTime to treatment initiationCase findingCox regression modelsStructured questionnaireInitiation of treatmentTreatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial
Charalambous S, Maraba N, Jennings L, Rabothata I, Cogill D, Mukora R, Hippner P, Naidoo P, Xaba N, Mchunu L, Velen K, Orrell C, Fielding K. Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial. EClinicalMedicine 2024, 75: 102745. PMID: 39170937, PMCID: PMC11338121, DOI: 10.1016/j.eclinm.2024.102745.Peer-Reviewed Original ResearchEvidence of improved adherenceTreatment adherencePrimary health clinicsCluster randomised trialCluster randomized trialStandard of careDifferentiated care approachesPoor treatment adherenceMedical monitoringCare approachHealth clinicsAdherence reportsLower treatment completionCluster designDrug-susceptible tuberculosisPrimary outcomeRandomised trialsDrug-sensitive tuberculosisAdherenceTreatment completionCareParticipantsSouth AfricaRandomized trialsFollow-upReaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation
Hoffmann C, Herce M, Chimoyi L, Smith H, Tlali M, Olivier C, Topp S, Muyoyeta M, Reid S, Hausler H, Charalambous S, Fielding K. Reaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 465-471. PMID: 38985444, DOI: 10.1097/qai.0000000000003456.Peer-Reviewed Original ResearchHIV testingCross-sectional analysisAntiretroviral therapyCoverage of HIV testingHIV statusHIV testing coverageUniversal testingHIV epidemic controlTreatment dataCohort-based studyAntiretroviral therapy initiationRoutine dataUTT implementationBackground PeopleCorrectional facilitiesCensus listsZambian sitesHIVSouth AfricaSouth African sitesEpidemic controlUTTCorrectional settingsTherapyFacilitiesLung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa
Glover N, Ivanova O, Sathar F, Riess F, Shambhu R, Mekota A, Zurba L, Menezes C, van Blydenstein S, Kalla I, Hoelscher M, Saathoff E, Charalambous S, Rachow A. Lung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa. EClinicalMedicine 2024, 71: 102588. PMID: 38623400, PMCID: PMC11016864, DOI: 10.1016/j.eclinm.2024.102588.Peer-Reviewed Original ResearchSt George's Respiratory QuestionnaireBody mass indexWorld Health OrganizationRisk factorsChest CTAssessed body mass indexSARS-CoV-2 infectionCOVID-19 severityTB diseaseGeorge's Respiratory QuestionnaireMedian 6MWT distanceChris Hani Baragwanath Academic HospitalSt George's Respiratory Questionnaire total scoreQuality of lifeGt;35 kg/m<sup>2</sup>High-resolution chest CTObservational cohort studySingle-centre cohortPost-SARS-CoV-2 infectionRespiratory QuestionnairePost-COVID-19 sequelaePost-dischargeSARS-CoV-2Significant risk factorsHospitalised adultsA pilot cross-sectional study of non-communicable diseases in TB household contacts
Hamada Y, Lugendo A, Ntshiqa T, Kubeka G, Lalashowi J, Mwastaula S, Ntshamane K, Sabi I, Wilson S, Copas A, Velen K, Ntinginya N, Minja L, Abubakar I, Charalambous S, Rangaka M. A pilot cross-sectional study of non-communicable diseases in TB household contacts. IJTLD OPEN 2024, 1: 154-159. PMID: 38988408, PMCID: PMC11231826, DOI: 10.5588/ijtldopen.23.0579.Peer-Reviewed Original ResearchNon-communicable diseasesTB household contactsNon-communicable disease screeningStudy of non-communicable diseasePrevalence of non-communicable diseasesPilot cross-sectional studyContact investigationCross-sectional studyIntegrated screeningHousehold contactsHemoglobin A1cNeighborhood householdsPrevalenceBlood pressureBlood glucoseSouth AfricaAdult contactsScreeningCareNeighborhoodIndividualsA1cDiabetesDiseasePilotExploring the syndemic interaction between social, environmental and structural contexts of HIV infection in peri-mining areas in South Africa: a qualitative study
Chimoyi L, Ndini P, Oladimeji M, Seatlholo N, Mawokomatanda K, Charalambous S, Setswe G. Exploring the syndemic interaction between social, environmental and structural contexts of HIV infection in peri-mining areas in South Africa: a qualitative study. BMJ Open 2024, 14: e076198. PMID: 38521520, PMCID: PMC10961556, DOI: 10.1136/bmjopen-2023-076198.Peer-Reviewed Original ResearchConceptsFemale sex workersFocus group discussionsIn-depth interviewsInjection drug usersUptake of HIV prevention servicesHealthcare workersHIV prevention servicesHIV infectionHIV prevention programmesPre-exposure prophylaxisAssociated with HIV acquisitionAccessibility to alcoholSocio-behavioral factorsCommunity-based organisationsPreventive servicesHIV prevalencePrevention programmesAreas of South AfricaSyndemic factorsQualitative studyHIV transmissionHIV acquisitionInclusion criteriaFactors affecting peopleSex workersFeasibility and acceptability of the smart pillbox and medication label with differentiated care to support person-centered tuberculosis care among ASCENT trial participants – A multicountry study
Tadesse A, Mganga A, Dube T, Alacapa J, van Kalmthout K, Letta T, Mleoh L, Garfin A, Maraba N, Charalambous S, Foster N, Jerene D, Fielding K. Feasibility and acceptability of the smart pillbox and medication label with differentiated care to support person-centered tuberculosis care among ASCENT trial participants – A multicountry study. Frontiers In Public Health 2024, 12: 1327971. PMID: 38444445, PMCID: PMC10913790, DOI: 10.3389/fpubh.2024.1327971.Peer-Reviewed Original ResearchDigital adherence technologiesMedication labelsPragmatic cluster randomized trialBehaviour (COM-BPhone ownershipFacility-level clusteringCluster randomized trialCross-sectional surveyLikert-scale responsesCOM-BHealth facilitiesDisclosure concernsTB burden settingsTB projectMedication adherenceTuberculosis careDifferentiated carePillbox usersPhone accessTrial participantsMean scoreCare supportMulticountry studyLabel usersBurden settings