2012
Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs
Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs. PLOS ONE 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.Peer-Reviewed Original ResearchConceptsMetastatic progressionWidespread metastatic diseaseLower ratesPolymetastatic progressionCurative intentInitial metastasisMetastatic diseaseSurgical resectionMetastasis samplesLimited progressionPatientsDistinct entityProgressionLatter groupRecurrenceMetastasisHigh rateIndependent validation datasetExpression patternsOligometastasesResectionMicroRNAsRadiotherapyLungValidation dataset
2011
MicroRNA Expression Characterizes Oligometastasis(es)
Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA Expression Characterizes Oligometastasis(es). PLOS ONE 2011, 6: e28650. PMID: 22174856, PMCID: PMC3236765, DOI: 10.1371/journal.pone.0028650.Peer-Reviewed Original ResearchConceptsOligometastatic patientsMetastasis-directed treatmentMetastasis-directed therapyHigh-dose radiotherapyPredictors of progressionMicroRNA-200 (miR-200) familyPolymetastatic progressionMetastatic diseasePatient selectionLocal treatmentCancer stagingMetastatic outcomeXenograft modelMicroRNA classifierPatientsPolymetastasesTumor samplesOligometastasesCell linesTreatmentProgressionBiological basisRadiotherapyExpressionTherapy