Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs
Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and Polymetastatic Progression in Lung Metastasis(es) Patients Is Associated with Specific MicroRNAs. PLOS ONE 2012, 7: e50141. PMID: 23251360, PMCID: PMC3518475, DOI: 10.1371/journal.pone.0050141.Peer-Reviewed Original ResearchConceptsMetastatic progressionWidespread metastatic diseaseLower ratesPolymetastatic progressionCurative intentInitial metastasisMetastatic diseaseSurgical resectionMetastasis samplesLimited progressionPatientsDistinct entityProgressionLatter groupRecurrenceMetastasisHigh rateIndependent validation datasetExpression patternsOligometastasesResectionMicroRNAsRadiotherapyLungValidation dataset