Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma
Hasan NM, Sharma A, Ruzgar NM, Deshpande H, Olino K, Khan S, Ahuja N. Epigenetic signatures differentiate uterine and soft tissue leiomyosarcoma. Oncotarget 2021, 12: 1566-1579. PMID: 34381562, PMCID: PMC8351604, DOI: 10.18632/oncotarget.28032.Peer-Reviewed Original ResearchDNA methylationGene expressionSubtype-specific gene expressionDifferential DNA methylationGene expression patternsPromoter CpG islandsRNA-seq dataEpigenetic regulationEpigenetic profilingEpigenetic signaturesCpG islandsEpigenetic alterationsExpression patternsGenesMethylationUnsupervised hierarchical clusteringPotential therapeutic targetMolecular landscapeIntegrated analysisMain clustersPotential targetTherapeutic targetExpressionSubtype-specific differencesMultiple aspects