2020
Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases
Kurbatov V, Resio BJ, Cama CA, Heller DR, Cha C, Zhang Y, Lu J, Khan SA. Liver-first approach to stage IV colon cancer with synchronous isolated liver metastases. Journal Of Gastrointestinal Oncology 2020, 11: 76-83. PMID: 32175108, PMCID: PMC7052756, DOI: 10.21037/jgo.2020.01.03.Peer-Reviewed Original ResearchLiver-first approachIsolated liver metastasesColon adenocarcinomaLiver metastasesMultivariable Cox proportional hazards analysisCox proportional hazards analysisNational Cancer DatabaseProportional hazards analysisRisk of deathCompletion resectionResection sequenceUpfront chemotherapyExtrahepatic metastasesMedian survivalClinical outcomesHepatic metastasesCAC patientsKaplan-MeierMetastatic tumorsCancer DatabaseColon cancerCAC casesPatientsMetastasisGreater likelihood
2019
APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival
Rubinstein JC, Khan SA, Christison‐Lagay E, Cha C. APC mutational patterns in gastric adenocarcinoma are enriched for missense variants with associated decreased survival. Genes Chromosomes And Cancer 2019, 59: 64-68. PMID: 31353684, DOI: 10.1002/gcc.22792.Peer-Reviewed Original ResearchGenomic Data CommonsSingle nucleotide variantsAPC mutationsMutational patternsMissense mutationsSpecific APC mutationsMissense variantsRecurrent somatic eventsProtein dysfunctionAdenomatous polyposis coli (APC) mutationsNucleotide variantsSpecific mutational patternsSomatic eventsMutationsNumerous tumor typesResultant clinical manifestationsDifferent mutationsFuture risk stratification strategiesFamilial adenomatous polyposisData CommonsVariantsColon adenocarcinomaColon cancerGenesColon tumors