Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human Cancers
Pitroda SP, Zhou T, Sweis RF, Filippo M, Labay E, Beckett MA, Mauceri HJ, Liang H, Darga TE, Perakis S, Khan SA, Sutton HG, Zhang W, Khodarev NN, Garcia JG, Weichselbaum RR. Tumor Endothelial Inflammation Predicts Clinical Outcome in Diverse Human Cancers. PLOS ONE 2012, 7: e46104. PMID: 23056240, PMCID: PMC3464251, DOI: 10.1371/journal.pone.0046104.Peer-Reviewed Original ResearchConceptsEndothelial inflammationEndothelial cellsOverall survivalHuman cancersDiverse human cancersExperimental modelTumor-associated endothelial cellsStromal inflammatory responsePathological prognostic factorsEndothelial-derived factorsPro-inflammatory cytokinesInflammatory gene expressionPathologic tissue specimensUntreated endothelial cellsVascular endothelial cellsMultiple human cancersInflammatory signatureHuman endothelial cellsPrognostic factorsClinical outcomesChronic inflammationInflammatory pathwaysLung cancerTumor necrosisInflammatory response