2021
Systemic Adaptive Immune Parameters Associated with Neuroblastoma Outcomes: the Significance of Gamma-Delta T Cells
Gozlan EC, Chobrutskiy BI, Zaman S, Yeagley M, Blanck G. Systemic Adaptive Immune Parameters Associated with Neuroblastoma Outcomes: the Significance of Gamma-Delta T Cells. Journal Of Molecular Neuroscience 2021, 71: 2393-2404. PMID: 33666857, DOI: 10.1007/s12031-021-01813-x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityBrain NeoplasmsHumansIntraepithelial LymphocytesNeuroblastomaReceptors, ImmunologicSurvival AnalysisConceptsGamma delta T cellsImmune receptor recombinationsAdaptive immune responsesT cellsImmune responseLower overall survival rateSet of neuroblastomaSystemic immune stateOverall survival rateAdaptive immune parametersImmunology parametersActive diseaseDevelopment of cancerYounger patientsImmune parametersImmune stateCancer evaluationNeuroblastoma outcomeSurvival rateImmunity developmentYounger ageTumor samplesAntigenic specificityImmune receptorsReceptor gene
2018
Recovery of T-cell receptor V(D)J recombination reads from lower grade glioma exome files correlates with reduced survival and advanced cancer grade
Chobrutskiy BI, Zaman S, Tong WL, Diviney A, Blanck G. Recovery of T-cell receptor V(D)J recombination reads from lower grade glioma exome files correlates with reduced survival and advanced cancer grade. Journal Of Neuro-Oncology 2018, 140: 697-704. PMID: 30382482, DOI: 10.1007/s11060-018-03001-1.Peer-Reviewed Original ResearchConceptsLow-grade gliomasT cell receptorCancer gradeImmune systemExome filesT-cell biomarkersDisease-free survivalT lymphocyte infiltrationPrimary tumor siteLGG survivalLymphocyte infiltrationCancer survivalPrimary tumorPancreatic cancerDisease progressionUseful biomarkerB cellsGrade gliomasSurvival rateTumor siteReduced survivalSurvivalSuch associationsBiomarkersReceptors