2017
Longitudinal analysis of treatment-induced genomic alterations in gliomas
Erson-Omay EZ, Henegariu O, Omay SB, Harmancı AS, Youngblood MW, Mishra-Gorur K, Li J, Özduman K, Carrión-Grant G, Clark VE, Çağlar C, Bakırcıoğlu M, Pamir MN, Tabar V, Vortmeyer AO, Bilguvar K, Yasuno K, DeAngelis LM, Baehring JM, Moliterno J, Günel M. Longitudinal analysis of treatment-induced genomic alterations in gliomas. Genome Medicine 2017, 9: 12. PMID: 28153049, PMCID: PMC5290635, DOI: 10.1186/s13073-017-0401-9.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsChromosome AberrationsCombined Modality TherapyDisease ProgressionDNA Mismatch RepairDNA Mutational AnalysisDNA, NeoplasmExomeFemaleGeneral SurgeryGenome, HumanGenomicsGlioblastomaHumansImmunotherapyLongitudinal StudiesMiddle AgedMutationNeoplasm Recurrence, LocalPrecision MedicineRadiotherapyTreatment OutcomeConceptsWhole-exome sequencingMismatch repair deficiencyImmune checkpoint inhibitionMalignant brain tumorsMolecular changesLongitudinal analysisMedian survivalCheckpoint inhibitionSubsequent recurrenceMaximal resectionStandard treatmentBackgroundGlioblastoma multiformeBrain tumorsTumor-normal pairsFavorable responsePrimary GBMIndividual tumorsConclusionsOur studyPrecision therapyPersonalized treatmentGenomic profilingRepair deficiencyGenomic alterationsGenomic profilesTherapy
2009
Current concepts and newer developments in the treatment of malignant gliomas
Omay S, Vogelbaum M. Current concepts and newer developments in the treatment of malignant gliomas. Indian Journal Of Cancer 2009, 46: 88-95. PMID: 19346642, DOI: 10.4103/0019-509x.49146.Peer-Reviewed Original ResearchConceptsMalignant gliomasPrimary malignant brain tumorCancer-related disabilityMalignant glioma patientsStandard treatment modalityGlioma cell biologyMalignant brain tumorsNew treatment strategiesTreatment modalitiesChallenging tumorsSystemic administrationNovel therapiesTreatment strategiesAdult cancersGlioma patientsRadiation therapyBrain tumorsTherapyTumorsGliomasCurrent conceptsChemotherapyPatientsSurgeryGreater understanding