2023
Dynamic microtubules slow down during their shrinkage phase
Luchniak A, Kuo Y, McGuinness C, Sutradhar S, Orbach R, Mahamdeh M, Howard J. Dynamic microtubules slow down during their shrinkage phase. Biophysical Journal 2023, 122: 616-623. PMID: 36659852, PMCID: PMC9989939, DOI: 10.1016/j.bpj.2023.01.020.Peer-Reviewed Original Research
2022
Dynamic instability of dendrite tips generates the highly branched morphologies of sensory neurons
Shree S, Sutradhar S, Trottier O, Tu Y, Liang X, Howard J. Dynamic instability of dendrite tips generates the highly branched morphologies of sensory neurons. Science Advances 2022, 8: eabn0080. PMID: 35767611, PMCID: PMC9242452, DOI: 10.1126/sciadv.abn0080.Peer-Reviewed Original ResearchDynamic instability of dendritic tips generates complex neuronal morphologies
Sutradhar S, Shree S, Trottier O, Tu Y, Liang X, Howard J. Dynamic instability of dendritic tips generates complex neuronal morphologies. Biophysical Journal 2022, 121: 125a. DOI: 10.1016/j.bpj.2021.11.2110.Peer-Reviewed Original Research
2021
Focal laser stimulation of fly nociceptors activates distinct axonal and dendritic Ca2+ signals
Basak R, Sutradhar S, Howard J. Focal laser stimulation of fly nociceptors activates distinct axonal and dendritic Ca2+ signals. Biophysical Journal 2021, 120: 3222-3233. PMID: 34175294, PMCID: PMC8390926, DOI: 10.1016/j.bpj.2021.06.001.Peer-Reviewed Original Research
2020
Ordering kinetics in a q-state random-bond clock model: Role of vortices and interfaces
Chatterjee S, Sutradhar S, Puri S, Paul R. Ordering kinetics in a q-state random-bond clock model: Role of vortices and interfaces. Physical Review E 2020, 101: 032128. PMID: 32290025, DOI: 10.1103/physreve.101.032128.Peer-Reviewed Original ResearchQ-state clock modelClock modelDisorder-dependent exponentNonequilibrium coarsening dynamicsMonte Carlo studyPower-law growthDynamical scalingInfinite temperatureQuenched disorderCoarsening dynamicsRole of vorticesCorrelation functionsStrength εCarlo studyTemperature T.Structure factorPhase transitionPure caseGrowth exponentInitial configurationDomain coarseningSimulation timescalesExponentDynamicsQuenchThe Growth Dynamics of Drosophila Class IV Dendrites Accords with a Three-State Markov Model
Sutradhar S, Shree S, Trottier O, Howard J. The Growth Dynamics of Drosophila Class IV Dendrites Accords with a Three-State Markov Model. Biophysical Journal 2020, 118: 456a-457a. DOI: 10.1016/j.bpj.2019.11.2543.Peer-Reviewed Original ResearchPredicting the Morphology of Class IV Neurons from the Dynamics of Dendritic Growth in Drosophila
Trottier O, Sutradhar S, Shree S, Howard J. Predicting the Morphology of Class IV Neurons from the Dynamics of Dendritic Growth in Drosophila. Biophysical Journal 2020, 118: 288a. DOI: 10.1016/j.bpj.2019.11.1637.Peer-Reviewed Original Research
2019
A novel combinatorial approach of quantitative microscopy and in silico modeling deciphers Arf1-dependent Golgi size regulation
Iyer P, Sutradhar S, Paul R, Bhattacharyya D. A novel combinatorial approach of quantitative microscopy and in silico modeling deciphers Arf1-dependent Golgi size regulation. The European Physical Journal E 2019, 42: 154. PMID: 31834534, DOI: 10.1140/epje/i2019-11920-x.Peer-Reviewed Original Research
2016
Phase segregation in a binary fluid confined inside a nanopore
Basu S, Majumder S, Sutradhar S, Das S, Paul R. Phase segregation in a binary fluid confined inside a nanopore. EPL (Europhysics Letters) 2016, 116: 56003. DOI: 10.1209/0295-5075/116/56003.Peer-Reviewed Original ResearchEB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice
Thomas G, Bandopadhyay K, Sutradhar S, Renjith M, Singh P, Gireesh K, Simon S, Badarudeen B, Gupta H, Banerjee M, Paul R, Mitra J, Manna T. EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice. Nature Communications 2016, 7: 11665. PMID: 27225956, PMCID: PMC4894954, DOI: 10.1038/ncomms11665.Peer-Reviewed Original ResearchConceptsMicrotubule attachmentMicrotubule plus-end tracking protein EB1Plus-end tracking protein EB1Dynamic microtubulesMitotic chromosome alignmentMicrotubule latticeVertebrate cellsProtein complexesChromosome movementChromosome alignmentProtein EB1Biochemical experimentsEB1K-fibersDepletion resultsMicrotubulesVertebratesStructural studiesExtended structureSKA1EukaryotesKinetochoresImportant roleMitosisProtein
2015
Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability
Sutradhar S, Basu S, Paul R. Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability. Physical Review E 2015, 92: 042714. PMID: 26565279, DOI: 10.1103/physreve.92.042714.Peer-Reviewed Original ResearchConceptsMammalian cellsProper spindle formationBipolar mitotic spindleDifferent motor proteinsMost mammalian cellsStable bipolar spindleProper segregationDaughter cellsSpindle stabilityCell divisionMitotic spindleSpindle formationSpindle instabilityBipolar spindleDifferent physiological constraintsCell biologyMotor proteinsChromosomal configurationsInterpolar microtubulesPhysiological constraintsSpindle lengthChromosomal patternCellsMechanistic modelCrucial roleA comprehensive model to predict mitotic division in budding yeasts
Sutradhar S, Yadav V, Sridhar S, Sreekumar L, Bhattacharyya D, Ghosh S, Paul R, Sanyal K. A comprehensive model to predict mitotic division in budding yeasts. Molecular Biology Of The Cell 2015, 26: 3954-3965. PMID: 26310442, PMCID: PMC4710229, DOI: 10.1091/mbc.e15-04-0236.Peer-Reviewed Original ResearchConceptsCell divisionNuclear migrationChromosome segregationCytoplasmic microtubulesHigh-fidelity chromosome segregationMitotic cell divisionSystems biology approachSpindle orientationSpindle alignmentBiology approachMajor phylaMitotic eventsMitotic divisionMicrotubule dynamicsDistinct pathwaysYeastMinimal computational modelCortical dyneinPhylaDivisionEffects of perturbationsAscomycotaBasidiomycotaMigrationInterdependent interactions
2014
Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase
Sau S, Sutradhar S, Paul R, Sinha P. Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase. PLOS ONE 2014, 9: e101294. PMID: 25003500, PMCID: PMC4086815, DOI: 10.1371/journal.pone.0101294.Peer-Reviewed Original ResearchConceptsSpindle pole bodyKinetochore proteinsKinetochore componentsLate anaphaseYeast kinetochore proteinsCentromere/kinetochoreMicrotubule-dependent forcesKinetochore microtubule dynamicsProtein-protein interactionsKinetochore-microtubule interactionsWild-type cellsPolar ejection forcesCtf19 complexFunctional kinetochoreProtein complexesPole bodyMutant cellsKinetochoresCentromeresComplex membersMicrotubule dynamicsCell cycleCtf19pRescue frequencyPhysical interaction
2013
Tug-of-war between opposing molecular motors explains chromosomal oscillation during mitosis
Sutradhar S, Paul R. Tug-of-war between opposing molecular motors explains chromosomal oscillation during mitosis. Journal Of Theoretical Biology 2013, 344: 56-69. PMID: 24333041, DOI: 10.1016/j.jtbi.2013.11.023.Peer-Reviewed Original Research