2015
Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability
Sutradhar S, Basu S, Paul R. Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability. Physical Review E 2015, 92: 042714. PMID: 26565279, DOI: 10.1103/physreve.92.042714.Peer-Reviewed Original ResearchConceptsMammalian cellsProper spindle formationBipolar mitotic spindleDifferent motor proteinsMost mammalian cellsStable bipolar spindleProper segregationDaughter cellsSpindle stabilityCell divisionMitotic spindleSpindle formationSpindle instabilityBipolar spindleDifferent physiological constraintsCell biologyMotor proteinsChromosomal configurationsInterpolar microtubulesPhysiological constraintsSpindle lengthChromosomal patternCellsMechanistic modelCrucial roleA comprehensive model to predict mitotic division in budding yeasts
Sutradhar S, Yadav V, Sridhar S, Sreekumar L, Bhattacharyya D, Ghosh S, Paul R, Sanyal K. A comprehensive model to predict mitotic division in budding yeasts. Molecular Biology Of The Cell 2015, 26: 3954-3965. PMID: 26310442, PMCID: PMC4710229, DOI: 10.1091/mbc.e15-04-0236.Peer-Reviewed Original ResearchMeSH KeywordsChromosome SegregationCytoplasmCytoplasmic DyneinsDyneinsMicrotubulesMitosisModels, BiologicalSaccharomycetalesSpindle ApparatusConceptsCell divisionNuclear migrationChromosome segregationCytoplasmic microtubulesHigh-fidelity chromosome segregationMitotic cell divisionSystems biology approachSpindle orientationSpindle alignmentBiology approachMajor phylaMitotic eventsMitotic divisionMicrotubule dynamicsDistinct pathwaysYeastMinimal computational modelCortical dyneinPhylaDivisionEffects of perturbationsAscomycotaBasidiomycotaMigrationInterdependent interactions
2014
Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase
Sau S, Sutradhar S, Paul R, Sinha P. Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase. PLOS ONE 2014, 9: e101294. PMID: 25003500, PMCID: PMC4086815, DOI: 10.1371/journal.pone.0101294.Peer-Reviewed Original ResearchConceptsSpindle pole bodyKinetochore proteinsKinetochore componentsLate anaphaseYeast kinetochore proteinsCentromere/kinetochoreMicrotubule-dependent forcesKinetochore microtubule dynamicsProtein-protein interactionsKinetochore-microtubule interactionsWild-type cellsPolar ejection forcesCtf19 complexFunctional kinetochoreProtein complexesPole bodyMutant cellsKinetochoresCentromeresComplex membersMicrotubule dynamicsCell cycleCtf19pRescue frequencyPhysical interaction