2016
EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice
Thomas G, Bandopadhyay K, Sutradhar S, Renjith M, Singh P, Gireesh K, Simon S, Badarudeen B, Gupta H, Banerjee M, Paul R, Mitra J, Manna T. EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice. Nature Communications 2016, 7: 11665. PMID: 27225956, PMCID: PMC4894954, DOI: 10.1038/ncomms11665.Peer-Reviewed Original ResearchConceptsMicrotubule attachmentMicrotubule plus-end tracking protein EB1Plus-end tracking protein EB1Dynamic microtubulesMitotic chromosome alignmentMicrotubule latticeVertebrate cellsProtein complexesChromosome movementChromosome alignmentProtein EB1Biochemical experimentsEB1K-fibersDepletion resultsMicrotubulesVertebratesStructural studiesExtended structureSKA1EukaryotesKinetochoresImportant roleMitosisProtein
2015
Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability
Sutradhar S, Basu S, Paul R. Intercentrosomal angular separation during mitosis plays a crucial role for maintaining spindle stability. Physical Review E 2015, 92: 042714. PMID: 26565279, DOI: 10.1103/physreve.92.042714.Peer-Reviewed Original ResearchConceptsMammalian cellsProper spindle formationBipolar mitotic spindleDifferent motor proteinsMost mammalian cellsStable bipolar spindleProper segregationDaughter cellsSpindle stabilityCell divisionMitotic spindleSpindle formationSpindle instabilityBipolar spindleDifferent physiological constraintsCell biologyMotor proteinsChromosomal configurationsInterpolar microtubulesPhysiological constraintsSpindle lengthChromosomal patternCellsMechanistic modelCrucial roleA comprehensive model to predict mitotic division in budding yeasts
Sutradhar S, Yadav V, Sridhar S, Sreekumar L, Bhattacharyya D, Ghosh S, Paul R, Sanyal K. A comprehensive model to predict mitotic division in budding yeasts. Molecular Biology Of The Cell 2015, 26: 3954-3965. PMID: 26310442, PMCID: PMC4710229, DOI: 10.1091/mbc.e15-04-0236.Peer-Reviewed Original ResearchConceptsCell divisionNuclear migrationChromosome segregationCytoplasmic microtubulesHigh-fidelity chromosome segregationMitotic cell divisionSystems biology approachSpindle orientationSpindle alignmentBiology approachMajor phylaMitotic eventsMitotic divisionMicrotubule dynamicsDistinct pathwaysYeastMinimal computational modelCortical dyneinPhylaDivisionEffects of perturbationsAscomycotaBasidiomycotaMigrationInterdependent interactions
2014
Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase
Sau S, Sutradhar S, Paul R, Sinha P. Budding Yeast Kinetochore Proteins, Chl4 and Ctf19, Are Required to Maintain SPB-Centromere Proximity during G1 and Late Anaphase. PLOS ONE 2014, 9: e101294. PMID: 25003500, PMCID: PMC4086815, DOI: 10.1371/journal.pone.0101294.Peer-Reviewed Original ResearchConceptsSpindle pole bodyKinetochore proteinsKinetochore componentsLate anaphaseYeast kinetochore proteinsCentromere/kinetochoreMicrotubule-dependent forcesKinetochore microtubule dynamicsProtein-protein interactionsKinetochore-microtubule interactionsWild-type cellsPolar ejection forcesCtf19 complexFunctional kinetochoreProtein complexesPole bodyMutant cellsKinetochoresCentromeresComplex membersMicrotubule dynamicsCell cycleCtf19pRescue frequencyPhysical interaction
2013
Tug-of-war between opposing molecular motors explains chromosomal oscillation during mitosis
Sutradhar S, Paul R. Tug-of-war between opposing molecular motors explains chromosomal oscillation during mitosis. Journal Of Theoretical Biology 2013, 344: 56-69. PMID: 24333041, DOI: 10.1016/j.jtbi.2013.11.023.Peer-Reviewed Original Research