2023
Microglia in Central Control of Metabolism
Kim J, Copperi F, Diano S. Microglia in Central Control of Metabolism. Physiology 2023, 39: 5-17. PMID: 37962895, PMCID: PMC11283896, DOI: 10.1152/physiol.00021.2023.Peer-Reviewed Original Research
2017
POMC Neurons: From Birth to Death
Toda C, Santoro A, Kim JD, Diano S. POMC Neurons: From Birth to Death. Annual Review Of Physiology 2017, 79: 209-236. PMID: 28192062, PMCID: PMC5669621, DOI: 10.1146/annurev-physiol-022516-034110.Peer-Reviewed Original ResearchConceptsPro-opiomelanocortin (POMC) neuronsHypothalamic neuronal populationsPOMC neuronsBrain stemHypothalamic nucleiSpinal cordAutonomic regionsMelanocortin systemBrain areasNeuronal populationsNeuronal circuitsHomeostatic functionsBrain structuresPathological dysregulationHypothalamusCritical regulatorNeuronsPhysiological functionsCurrent understandingMajor roleCord
2015
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.Peer-Reviewed Original ResearchConceptsPOMC neuronsΒ-endorphinHypothalamic pro-opiomelanocortin (POMC) neuronsOpioid peptide β-endorphinHypothalamic POMC neuronsPromotion of feedingPro-opiomelanocortin (POMC) neuronsCannabinoid receptor 1CB1R activityPOMC activitySated miceHormone releaseHypothalamic administrationFood intakeCentral regulationNeuronal activityParadoxical increaseCB1RReceptor 1POMC cellsNeuronsMitochondrial adaptationsDecreased activityPOMC geneUnsuspected role