Evidence Showing That β-Endorphin Regulates Cyclic Guanosine 3′,5′-Monophosphate (cGMP) Efflux: Anatomical and Functional Support for an Interaction between Opiates and Nitric Oxide*
Pu S, Horvath T, Diano S, Naftolin F, Kalra P, Kalra S. Evidence Showing That β-Endorphin Regulates Cyclic Guanosine 3′,5′-Monophosphate (cGMP) Efflux: Anatomical and Functional Support for an Interaction between Opiates and Nitric Oxide*. Endocrinology 1997, 138: 1537-1543. DOI: 10.1210/en.138.4.1537.Peer-Reviewed Original ResearchN-methyl-D-aspartateExcitatory amino acidsCyclic guanosine 3',5'-monophosphateMedial preoptic areaOpioid influenceGnRH secretionNitric oxideExcitatory N-methyl-D-aspartateN-methyl-D-aspartate receptorsPreoptic areaInhibitory opioid influenceB-endorphinOpiate receptor antagonistNOS-immunoreactive neuronsPituitary LH secretionNO releaseStimulation of NO releaseRelease of GnRHSubpopulations of neuronsGuanosine 3',5'-monophosphateCentral nervous systemReceptor agonistsReceptor antagonistEndogenous opioidsHypothalamic sections