2015
Hypothalamic POMC neurons promote cannabinoid-induced feeding
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519: 45-50. PMID: 25707796, PMCID: PMC4496586, DOI: 10.1038/nature14260.Peer-Reviewed Original ResearchConceptsPOMC neuronsΒ-endorphinHypothalamic pro-opiomelanocortin (POMC) neuronsOpioid peptide β-endorphinHypothalamic POMC neuronsPromotion of feedingPro-opiomelanocortin (POMC) neuronsCannabinoid receptor 1CB1R activityPOMC activitySated miceHormone releaseHypothalamic administrationFood intakeCentral regulationNeuronal activityParadoxical increaseCB1RReceptor 1POMC cellsNeuronsMitochondrial adaptationsDecreased activityPOMC geneUnsuspected role
1999
Interactions between Neuropeptide Y and γ -Aminobutyric Acid in Stimulation of Feeding: A Morphological and Pharmacological Analysis*
Pu S, Jain M, Horvath T, Diano S, Kalra P, Kalra S. Interactions between Neuropeptide Y and γ -Aminobutyric Acid in Stimulation of Feeding: A Morphological and Pharmacological Analysis*. Endocrinology 1999, 140: 933-940. DOI: 10.1210/en.140.2.933.Peer-Reviewed Original ResearchParaventricular nucleusStimulation of feedingNeuropeptide YG-aminobutyric acidFood intakeArcuate nucleusCoadministration of neuropeptide YNPY-induced food intakeSite of NPY actionEffects of muscimolGABAA receptor agonistDose-related fashionSubpopulations of NPY neuronsElectron microscopic double stainingRat brain sectionsFeeding responseSated ratsNPY neuronsReceptor agonistsNPY actionMessenger systemsMuscimolHypothalamic controlBrain stemGABA