Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus
Kaur A, Sanford H, Garry D, Lang S, Klumpp S, Watanabe D, Bronson R, Lifson J, Rosati M, Pavlakis G, Felber B, Knipe D, Desrosiers R. Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology 2006, 357: 199-214. PMID: 16962628, PMCID: PMC1819472, DOI: 10.1016/j.virol.2006.08.007.Peer-Reviewed Original ResearchConceptsSimian immunodeficiency virusELISPOT responsesImmunodeficiency virusHSV vectorsHerpes simplex virus vectorsPlasma SIV RNAPlasma viremia levelsVector-based vaccinesDay of challengeSimplex virus vectorsNef fusion proteinRecombinant HSV vectorsSIV RNAIntravenous challengeViremia levelsAntibody titersVaccine approachesImmune responseRhesus macaquesProtective capacityMacaquesRecombinant herpesvirusDNA vectorsFusion proteinEnv