2008
Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation
Buis J, Wu Y, Deng Y, Leddon J, Westfield G, Eckersdorff M, Sekiguchi JM, Chang S, Ferguson DO. Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation. Cell 2008, 135: 85-96. PMID: 18854157, PMCID: PMC2645868, DOI: 10.1016/j.cell.2008.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsCell Line, TransformedCell ProliferationDNA Breaks, Double-StrandedDNA DamageDNA RepairDNA Repair EnzymesDNA-Binding ProteinsFibroblastsGenomic InstabilityMiceMRE11 Homologue ProteinProtein Serine-Threonine KinasesRecombination, GeneticTelomereTumor Suppressor ProteinsConceptsMre11/Rad50/Nbs1Nuclease activityDNA repairDNA damageDramatic genomic instabilityFunctions of Mre11Early embryonic lethalityMre11 nuclease activityATM kinaseATR kinaseEmbryonic lethalityGenomic stabilityATM activationMRN complexNucleolytic processingBreak repairDNA endsATM signalingMouse alleleGenomic instabilityDNA nuclease activityNuclease deficienciesEssential functionsUnknown roleMre11
2003
Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression
Chang S, Khoo C, Naylor M, Maser R, DePinho R. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes & Development 2003, 17: 88-100. PMID: 12514102, PMCID: PMC195968, DOI: 10.1101/gad.1029903.Peer-Reviewed Original ResearchConceptsInk4a/Lung metastasesSubcutaneous tumorsTumor progressionTelomerase activationSubcutaneous tumor formationAdvanced human cancersTail vein injectionTelomere dysfunctionLate passagesMalignant endpointsTelomerase-independent alternative lengtheningImmunocompromised miceFunctional differencesCytogenetic profileMetastatic activityDysfunctionMetastasisCancer cell genomeTumor formationChromosomal aberrationsHuman cancersMarked increaseInitiated cellsMouse embryonic fibroblast cultures